ERC Advanced Investigator Group, Institute for Physiological Chemistry, University Medical Center of the Johannes Gutenberg University, Mainz, Germany.
Department of Dermatology, University Clinic Mainz, Mainz, Germany.
Prog Mol Subcell Biol. 2022;61:51-82. doi: 10.1007/978-3-031-01237-2_4.
Many pathological conditions are characterized by a deficiency of metabolic energy. A prominent example is nonhealing or difficult-to-heal chronic wounds. Because of their unique ability to serve as a source of metabolic energy, inorganic polyphosphates (polyP) offer the opportunity to develop novel strategies to treat such wounds. The basis is the generation of ATP from the polymer through the joint action of two extracellular or plasma membrane-bound enzymes alkaline phosphatase and adenylate kinase, which enable the transfer of energy-rich phosphate from polyP to AMP with the formation of ADP and finally ATP. Building on these findings, it was possible to develop novel regeneratively active materials for wound therapy, which have already been successfully evaluated in first studies on patients.
许多病理状况的特征是代谢能量不足。一个突出的例子是难以愈合或难以愈合的慢性伤口。由于无机多磷酸盐 (polyP) 具有独特的作为代谢能量源的能力，因此为开发治疗此类伤口的新策略提供了机会。其基础是通过两种细胞外或质膜结合的酶碱性磷酸酶和腺苷酸激酶的共同作用，从聚合物中生成 ATP，从而使高能磷酸盐从 polyP 转移到 AMP，形成 ADP，最终形成 ATP。基于这些发现，有可能开发出用于伤口治疗的新型再生活性材料，这些材料已在对患者的初步研究中成功评估。
