Bland Jeffrey S
Integr Med (Encinitas). 2022 May;21(2):22-26.
Embedded within the Functional Medicine model is the potential for reversibility of altered function. This perspective is inherently different from the Mendelian concept of genetics, which is grounded in the construct of dominate and recessive genetic characteristics. Mendel's work was obviously groundbreaking, but it has also contributed to a deterministic mindset about disease. Many people-even today-believe that health and disease are locked into the genes of every individual. Modern genomic research continues to reveal that the concept of genetic determinism can be (and should be) challenged. The functional interaction of our lifestyle, diet, environment, behavior, and social structure with our genome and epigenome greatly determines our health outcomes. It has been discovered that our aging epigenome can even be rejuvenated. The epigenomic structure is also a powerful predictor of disease outcome and life expectancy. As our understanding of genetic and epigenetic expression patterns grows, the implications for personalized Functional Medicine intervention programs are truly revolutionary.
功能医学模式蕴含着功能改变可逆的可能性。这种观点与孟德尔遗传学概念有着本质区别，孟德尔遗传学概念基于显性和隐性遗传特征的构建。孟德尔的工作显然具有开创性，但它也促成了一种关于疾病的决定论思维方式。许多人——即使在今天——仍然认为健康和疾病由每个人的基因决定。现代基因组研究不断揭示，基因决定论的概念是可以（而且应该）受到挑战的。我们的生活方式、饮食、环境、行为和社会结构与我们的基因组和表观基因组之间的功能相互作用在很大程度上决定了我们的健康结果。人们发现，我们衰老的表观基因组甚至可以恢复活力。表观基因组结构也是疾病结局和预期寿命的有力预测指标。随着我们对基因和表观遗传表达模式的理解不断深入，个性化功能医学干预计划的意义将带来真正的变革。
