School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang110016, People's Republic of China.
Faculty of Pharmaceutical Sciences, Toho University, Miyama 2-2-1, Funabashi, Chiba274-8510, Japan.
J Nat Prod. 2022 Jun 24;85(6):1658-1664. doi: 10.1021/acs.jnatprod.1c01195. Epub 2022 Jun 14.
Tigliane-type diterpenoids have attracted much attention in drug discovery since they have been reported to exhibit remarkable biological effects, such as tumor-promoting, antineoplastic, and anti-HIV activities. In continuing our efforts to discover novel biologically important diterpenoids from species, was investigated phytochemically for the first time. As a result, four new (-) and one known () tigliane-type diterpenoid were isolated, and their structures were elucidated by spectroscopic data analysis. Tiglianes (-) showed potent anti-HIV activity against HIV-1 infection of MT4 lymphocytes with IC values of 1.1-65.4 nM.
自从报道具有显著的生物活性，如促进肿瘤生长、抗癌和抗 HIV 活性以来，雷公藤型二萜类化合物在药物发现中引起了广泛关注。在继续从 种中发现新型具有重要生物学意义的二萜类化合物的努力中，首次对 进行了植物化学研究。结果，分离得到了四个新的（-）和一个已知的（）雷公藤型二萜类化合物，并通过光谱数据分析阐明了它们的结构。Tiglianes (-) 对 MT4 淋巴细胞中 HIV-1 感染表现出很强的抗 HIV 活性，IC 值为 1.1-65.4 nM。
