Department of Food Science and Biotechnology, National Chung Hsing University, 145 Xingda Road, Taichung 40227, Taiwan.
Food Funct. 2022 Jul 4;13(13):7168-7180. doi: 10.1039/d1fo04418d.
Food intake influences neurofunction the gut microbiota-brain axis. Monounsaturated fatty acid (MUFA) consumption is highly associated with neuroprotection; the mechanism behind the effects of olive oil and camellia oil on gut microbiota remains unclear. In this study, the objective was to compare the neuroprotective role of oleic acid-rich camellia oil and olive oil against AlCl-induced mild cognitive impairment (MCI) in rats. Morris water maze tests revealed that learning and memory capacities improved in AlCl-induced rats subjected to camellia oil administration better than olive oil treatment. Moreover, the results showed that the camellia oil- and olive oil-treated AlCl-induced rat groups had significantly reduced oxidative stress and inflammatory cytokines. Notably, Spearman correlation analysis indicated that the inflammatory cytokines negatively correlated with the microbial strains (group and ) in response to camellia oil administration. Furthermore, abundance was significantly enhanced by camellia oil intake, which was highly positively associated with antioxidant activity expression. In conclusion, the novel data suggest that the outcomes of camellia oil consumption were superior to those of olive oil intake as camellia oil may have a beneficial effect on MCI protection and improvement through the gut microbiota-brain communication.
食物摄入会影响神经功能——肠道微生物群-脑轴。单不饱和脂肪酸（MUFA）的摄入与神经保护高度相关；橄榄油和山茶油对肠道微生物群影响的背后机制尚不清楚。在这项研究中，目的是比较富含油酸的山茶油和橄榄油对 AlCl 诱导的大鼠轻度认知障碍（MCI）的神经保护作用。水迷宫测试结果表明，与橄榄油处理相比，给予山茶油的 AlCl 诱导大鼠的学习和记忆能力得到了改善。此外，结果表明，山茶油和橄榄油处理的 AlCl 诱导大鼠组的氧化应激和炎症细胞因子明显减少。值得注意的是，Spearman 相关性分析表明，炎症细胞因子与山茶油给药后微生物菌株（组和 ）呈负相关。此外，山茶油摄入可显著增加 的丰度，与抗氧化活性表达呈高度正相关。总之，新的数据表明，山茶油的摄入效果优于橄榄油的摄入效果，因为山茶油可能通过肠道微生物群-脑通讯对 MCI 保护和改善具有有益作用。
