Chambers J B, Pryce D, Bland J M, Northfield T C
Gut. 1987 Mar;28(3):294-9. doi: 10.1136/gut.28.3.294.
A dose/response study has been carried out in seven patients with endoscopically proven duodenal ulcers in symptomatic remission, measuring intragastric pH and gastric acid output overnight after a bedtime dose of ranitidine (75 mg, 150 mg, and 300 mg); and the results have been compared with placebo and with bedtime cimetidine 400 mg. The currently recommended ranitidine maintenance dose (150 mg) was the optimum because it was significantly more effective than ranitidine 75 mg in terms of intragastric pH but not of acid output, and there was no difference from 300 mg in terms of either measurement. It was also significantly more effective than the currently recommended cimetidine maintenance dose (400 mg) in terms of inhibiting overnight acid output (92% vs 80% inhibition, p less than 0.05), and of maintaining intragastric pH above 5 (100% vs 17% of the overnight period, p less than 0.001).
对7例经内镜证实十二指肠溃疡且症状缓解的患者进行了一项剂量/反应研究，在睡前给予雷尼替丁（75毫克、150毫克和300毫克）后，测定整夜胃内pH值和胃酸分泌量；并将结果与安慰剂以及睡前服用400毫克西咪替丁的情况进行比较。目前推荐的雷尼替丁维持剂量（150毫克）是最佳剂量，因为就胃内pH值而言，它比75毫克雷尼替丁显著更有效，但在胃酸分泌量方面并非如此，而且在两种测量指标上与300毫克雷尼替丁均无差异。在抑制夜间胃酸分泌量方面（抑制率分别为92%和80%，p<0.05）以及使胃内pH值维持在5以上方面（整夜时间段分别为100%和17%，p<0.001），它也比目前推荐的西咪替丁维持剂量（400毫克）显著更有效。
