Finch P J, Ryan F P, Rogers K, Holt S
Gut. 1987 Mar;28(3):319-22. doi: 10.1136/gut.28.3.319.
Levels of lactic dehydrogenase and beta-glucuronidase were measured in gastric wash samples obtained from 445 patients over 40 years old attending a routine diagnostic endoscopy clinic. An index was derived from the two levels and used as a test for the presence of gastric cancer. Of the 24 patients with an endoscopic diagnosis of gastric cancer, 21 (91.3%) proved positive on this test, including all four cases of early gastric cancer, which were found at repeat endoscopy. The specificity of the test for gastric cancer was 81.3%. Among those patients with false positive results who had endoscopic biopsy were four out of the five cases of severe dysplasia, and four out of the 13 cases of type 2B intestinal metaplasia. Atrophic gastritis alone or with intestinal metaplasia was found in 95.9% of the false positives who were biopsied.
对445名40岁以上在常规诊断性内镜诊所接受检查的患者的洗胃样本进行了乳酸脱氢酶和β-葡萄糖醛酸酶水平检测。从这两个水平得出一个指数，并将其用作胃癌存在的检测指标。在24例经内镜诊断为胃癌的患者中，21例（91.3%）经该检测呈阳性，包括所有4例早期胃癌，这些早期胃癌是在重复内镜检查时发现的。该胃癌检测的特异性为81.3%。在内镜活检的假阳性患者中，5例重度发育异常中有4例，13例2B型肠化生中有4例。在接受活检的假阳性患者中，95.9%存在单独的萎缩性胃炎或伴有肠化生。
