Fielding J W, Ellis D J, Jones B G, Paterson J, Powell D J, Waterhouse J A, Brookes V S
Br Med J. 1980 Oct 11;281(6246):965-7. doi: 10.1136/bmj.281.6246.965.
In "early" gastric cancer the depth of invasion by the primary tumour is confined to the submucosa of the stomach. Out of 13228 cases of gastric cancer notified to the Birmingham Cancer Registry during 1960-9, 90 (0 . 7%) were identifed as early gastric cancer. The crude five-year survival rate of these 90 patients was 57 . 8% (age-adjusted rate 70 . 4%) compared with 3 . 7% (age-adjusted rate 4 . 7%) for all cases and 14 . 6% (age-adjusted rate 17 . 4%) for the cases treated radically. Prognostic factors established for gastric cancer pertained equally to early gastric cancer. Most of the 90 patients had had symptoms related to the gastrointestinal tract, but in contrast to patients with advanced gastric cancer only 19% had lost weight on admission. These findings suggest that early investigation of dyspeptic symptoms would increase the detection of early gastric cancer, the most important prognostic group identified in gastric cancer.
在“早期”胃癌中，原发肿瘤的浸润深度局限于胃黏膜下层。在1960年至1969年期间向伯明翰癌症登记处报告的13228例胃癌病例中，有90例（0.7%）被确诊为早期胃癌。这90例患者的粗五年生存率为57.8%（年龄调整率为70.4%），而所有病例的相应生存率为3.7%（年龄调整率为4.7%），接受根治性治疗的病例为14.6%（年龄调整率为17.4%）。确立的胃癌预后因素同样适用于早期胃癌。这90例患者中的大多数都有与胃肠道相关的症状，但与进展期胃癌患者不同的是，入院时只有19%的患者体重减轻。这些发现表明，对消化不良症状进行早期检查将增加早期胃癌的检出率，早期胃癌是在胃癌中确定的最重要的预后组。
