Universidade Federal de Uberlândia, Faculdade de Odontologia, Departamento de Periodontía e Implantodontia, Uberlândia, Brasil.
Universidade de Araraquara, Faculdade de Odontologia, Departamento de Diagnostico e Cirurgía, Araraquara, Brasil.
Acta Odontol Latinoam. 2022 Apr 30;35(1):3-9. doi: 10.54589/aol.35/1/3.
The aim of this study was to evaluate the osseointegration of implants placed in rat tibia sites grafted with Deproteinized Bovine Bone (DBB) and Native Bone (NB). Twenty-eight rats were divided into two groups according to the type of substrate in which the implants were to be placed: NB - implants placed in native bone; DBB - implants placed in areas grafted with DBB. In the DBB group, the bone defect was made and filled with the bone substitute 60 days before placing the implant. The animals were euthanized 15 or 45 days after implant placement. Osseointegration was assessed by the removal torque, volume of mineralized tissues around the implants (BV/TV), bone-implant contact (%BIC), and bone between threads (%BBT). The implants placed in NB presented higher removal torque (8.00 ± 1.26 Ncm vs. 2.33 ± 0.41 Ncm at 15 days and 22.00 ± 2.44 Ncm vs. 4.00 ± 1.41 Ncm at 45 days), higher %BV/TV (47.92 ± 1.54% vs. 33.33 ± 4.77% at 15 days and 70.06 ± 0.91% vs. 39.89±5.90%at 45 days), higher %BIC (39.68 ± 5.02% vs. 9.12 ± 5.56% at 15 days and 83.23 ± 4.42% vs. 18.81 ± 7.21% at 45 days), and higher %BBT (34.33 ± 5.42% vs. 13.24 ± 8.72% at 15 days and 82.33 ± 3.13% vs. 22.26 ± 8.27% at 45 days) than the implants placed in DBB grafted areas. The degree of osseointegration was lower in implants placed in the area grafted with DBB than in NB in rat tibias.
本研究旨在评估在脱蛋白牛骨（DBB）和天然骨（NB）移植部位植入的种植体的骨整合情况。将 28 只大鼠根据种植体植入部位的基质类型分为两组：NB-植入物植入在天然骨中；DBB-植入物植入用 DBB 移植的区域。在 DBB 组中，在植入植入物前 60 天，制作骨缺损并用骨替代物填充。植入物植入后 15 或 45 天处死动物。通过去除扭矩、种植体周围矿化组织的体积（BV/TV）、骨-种植体接触（%BIC）和螺纹间骨（%BBT）来评估骨整合情况。植入物在 NB 中的去除扭矩较高（15 天时为 8.00 ± 1.26 Ncm，45 天时为 22.00 ± 2.44 Ncm；15 天时为 22.00 ± 2.44 Ncm，45 天时为 4.00 ± 1.41 Ncm），%BV/TV 较高（15 天时为 47.92 ± 1.54%，45 天时为 70.06 ± 0.91%；15 天时为 33.33 ± 4.77%，45 天时为 39.89 ± 5.90%），%BIC 较高（15 天时为 39.68 ± 5.02%，45 天时为 83.23 ± 4.42%；15 天时为 9.12 ± 5.56%，45 天时为 18.81 ± 7.21%），%BBT 较高（15 天时为 34.33 ± 5.42%，45 天时为 82.33 ± 3.13%；15 天时为 13.24 ± 8.72%，45 天时为 22.26 ± 8.27%），比植入物在 DBB 移植部位的骨整合程度低。在大鼠胫骨中，植入物在 DBB 移植部位的骨整合程度低于 NB。
