Leartiker S. Coop., Markina-Xemein 48270, Spain.
Department of Orthopaedic Surgery and Traumatology, Clínica Universidad de Navarra, Pamplona, Spain.
Biomed Mater. 2022 Jun 27;17(4). doi: 10.1088/1748-605X/ac78b7.
This work identifies and describes different material-scaffold geometry combinations for cartilage tissue engineering (CTE). Previously reported potentially interesting scaffold geometries were tuned and printed using bioresorbable polycaprolactone and poly(lactide-b-ethylene) block copolymer. Medical grades of both polymers were 3D printed with fused filament fabrication technology within an ISO 7 classified cleanroom. Resulting scaffolds were then optically, mechanically and biologically tested. Results indicated that a few material-scaffold geometry combinations present potential for excellent cell viability as well as for an enhance of the chondrogenic properties of the cells, hence suggesting their suitability for CTE applications.
这项工作确定并描述了用于软骨组织工程（CTE）的不同材料-支架几何组合。先前报道的潜在有趣的支架几何形状经过调整并使用可生物吸收的聚己内酯和聚（乳酸-b-乙交酯）嵌段共聚物进行打印。这两种聚合物的医用级均使用熔融纤维制造技术在 ISO 7 级洁净室中进行 3D 打印。然后对得到的支架进行光学、机械和生物学测试。结果表明，几种材料-支架几何组合具有良好的细胞活力和增强细胞软骨生成特性的潜力，因此表明它们适用于 CTE 应用。
