Tornow Ralf-Peter, Odstrcilik Jan, Kolar Radim
Department of Ophthalmology, Friedrich-Alexander-University of Erlangen-Nuremberg, 91056 Erlangen, Germany.
Department of Biomedical Engineering, Faculty of Electrical Engineering and Communication, Brno University of Technology, 616 00 Brno, Czech Republic.
Biomed Opt Express. 2018 Nov 14;9(12):6237-6254. doi: 10.1364/BOE.9.006237. eCollection 2018 Dec 1.
We describe a low-cost, easy to use binocular instrument to acquire retinal video sequences of both eyes simultaneously. After image registration, cardiac cycle-induced pulsatile light attenuation changes can be measured quantitatively with high spatial and temporal resolution. Parameters such as amplitude, pulse form, and time shift between light attenuation changes can be calculated and compared between eye sides. Deviation from inter-eye symmetry can be not only an early sign of beginning eye diseases such as glaucoma but also a sign of pathological changes in the carotid arteries; hence, this method can improve the early detection of pathological changes. Important features compared to existing monocular instruments are a narrow band light source with the wavelength close to the peak of the blood extinction, and a proportional relationship of image intensity and light intensity, which are the main requirements for quantitative evaluation.
我们描述了一种低成本、易于使用的双目仪器，可同时获取双眼的视网膜视频序列。图像配准后，可通过高空间和时间分辨率定量测量心动周期引起的脉动光衰减变化。可以计算诸如振幅、脉冲形式以及光衰减变化之间的时间偏移等参数，并在两眼之间进行比较。两眼间对称性的偏差不仅可能是青光眼等眼部疾病早期的迹象，也可能是颈动脉病理变化的迹象；因此，该方法可以提高病理变化的早期检测率。与现有的单目仪器相比，重要特征包括波长接近血液消光峰值的窄带光源以及图像强度与光强度的比例关系，这是定量评估的主要要求。
