• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

探讨脂肪组织细胞外囊泡在生理学中的功能所面临的挑战。

The challenges of interrogating adipose tissue extracellular vesicle functions in physiology.

机构信息

Department of Cell Biology and Physiology, Washington University School of Medicine, St. Louis, MO, USA.

Department of Internal Medicine, Division of Endocrinology, Metabolism and Lipid Research, Washington University School of Medicine, St. Louis, MO, USA.

出版信息

Commun Biol. 2022 Jun 14;5(1):581. doi: 10.1038/s42003-022-03511-9.

DOI:10.1038/s42003-022-03511-9
PMID:35701664
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9197966/
Abstract

Adipose tissue-derived extracellular vesicles (EVs) are at the center of the budding field of EV signaling in metabolic regulation for their strong regulatory effects on local and systemic metabolism. This essay will highlight seminal studies in adipose tissue EV research, critically assess current adipose tissue EV research strategies and discuss the obstacles the field faces moving forward.

摘要

脂肪组织来源的细胞外囊泡（EVs）在 EV 信号转导领域中处于新兴领域的中心，因为它们对局部和全身代谢具有强大的调节作用。本文将重点介绍脂肪组织 EV 研究中的开创性研究，批判性地评估当前脂肪组织 EV 研究策略，并讨论该领域未来面临的障碍。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6555/9197966/326a38810041/42003_2022_3511_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6555/9197966/87af10f079a0/42003_2022_3511_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6555/9197966/326a38810041/42003_2022_3511_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6555/9197966/87af10f079a0/42003_2022_3511_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6555/9197966/326a38810041/42003_2022_3511_Fig2_HTML.jpg

相似文献

1
The challenges of interrogating adipose tissue extracellular vesicle functions in physiology.探讨脂肪组织细胞外囊泡在生理学中的功能所面临的挑战。
Commun Biol. 2022 Jun 14;5(1):581. doi: 10.1038/s42003-022-03511-9.
2
Beyond the Extracellular Vesicles: Technical Hurdles, Achieved Goals and Current Challenges When Working on Adipose Cells.超越细胞外囊泡：在研究脂肪细胞时遇到的技术障碍、已实现目标和当前挑战。
Int J Mol Sci. 2021 Mar 25;22(7):3362. doi: 10.3390/ijms22073362.
3
Preparing Adipogenic Hydrogel with Neo-Mechanical Isolated Adipose-Derived Extracellular Vesicles for Adipose Tissue Engineering.利用新机械分离的脂肪来源细胞外囊泡制备用于脂肪组织工程的成脂水凝胶。
Plast Reconstr Surg. 2022 Dec 1;150(6):1348e-1349e. doi: 10.1097/PRS.0000000000009686. Epub 2022 Sep 27.
4
Reply: Preparing Adipogenic Hydrogel with Neo-Mechanical Isolated Adipose-Derived Extracellular Vesicles for Adipose Tissue Engineering.回复：利用新机械分离的脂肪源性细胞外囊泡制备用于脂肪组织工程的成脂水凝胶。
Plast Reconstr Surg. 2022 Dec 1;150(6):1349e-1350e. doi: 10.1097/PRS.0000000000009687. Epub 2022 Sep 28.
5
Role of adipocyte-derived extracellular vesicles in vascular inflammation.脂肪细胞衍生的细胞外囊泡在血管炎症中的作用。
Free Radic Biol Med. 2021 Aug 20;172:58-64. doi: 10.1016/j.freeradbiomed.2021.04.031. Epub 2021 May 28.
6
Cholesterol efflux alterations in adolescent obesity: role of adipose-derived extracellular vesical microRNAs.青少年肥胖症中胆固醇外排的改变：脂肪衍生细胞外囊泡 microRNAs 的作用。
J Transl Med. 2019 Jul 22;17(1):232. doi: 10.1186/s12967-019-1980-6.
7
Adipose Extracellular Vesicles: Messengers From and to Macrophages in Regulating Immunometabolic Homeostasis or Disorders.脂肪细胞外囊泡：在调节免疫代谢稳态或紊乱中巨噬细胞的信息传递者。
Front Immunol. 2021 May 24;12:666344. doi: 10.3389/fimmu.2021.666344. eCollection 2021.
8
Current understanding of the role of microRNAs from adipose-derived extracellular vesicles in obesity.当前对脂肪细胞外囊泡中 microRNAs 在肥胖中的作用的理解。
Biochem Soc Trans. 2022 Feb 28;50(1):447-457. doi: 10.1042/BST20211031.
9
Muscle and Adipose Tissue Communicate with Extracellular Vesicles.肌肉和脂肪组织通过细胞外囊泡进行交流。
Int J Mol Sci. 2022 Jun 24;23(13):7052. doi: 10.3390/ijms23137052.
10
Supplementation with Extracellular Vesicles Derived from Adipose-Derived Stem Cells Increases Fat Graft Survival and Browning in Mice: A Cell-Free Approach to Construct Beige Fat from White Fat Grafting.脂肪来源干细胞衍生细胞外囊泡的补充可增加脂肪移植的存活率和棕色化：一种从白色脂肪移植构建米色脂肪的无细胞方法。
Plast Reconstr Surg. 2020 May;145(5):1183-1195. doi: 10.1097/PRS.0000000000006740.

引用本文的文献

1
Human Differentiated Adipocytes as Surrogate Mature Adipocytes for Adipocyte-Derived Extracellular Vesicle Analysis.人分化脂肪细胞作为替代成熟脂肪细胞用于脂肪细胞衍生细胞外囊泡分析
Cells. 2025 May 22;14(11):757. doi: 10.3390/cells14110757.
2
Subcutaneous adipose tissue: Implications in dermatological diseases and beyond.皮下脂肪组织：对皮肤病及其他领域的影响
Allergy. 2024 Dec;79(12):3310-3325. doi: 10.1111/all.16295. Epub 2024 Aug 29.
3
MicroRNA Profile of Mouse Adipocyte-Derived Extracellular Vesicles.小鼠脂肪细胞衍生细胞外囊泡的 microRNA 谱。

本文引用的文献

1
Associations Among Adipose Tissue Immunology, Inflammation, Exosomes and Insulin Sensitivity in People With Obesity and Nonalcoholic Fatty Liver Disease.肥胖和非酒精性脂肪性肝病患者的脂肪组织免疫学、炎症、外泌体与胰岛素敏感性的关系。
Gastroenterology. 2021 Sep;161(3):968-981.e12. doi: 10.1053/j.gastro.2021.05.008. Epub 2021 May 15.
2
Isolation and characterization of extracellular vesicle subpopulations from tissues.从组织中分离和表征细胞外囊泡亚群。
Nat Protoc. 2021 Mar;16(3):1548-1580. doi: 10.1038/s41596-020-00466-1. Epub 2021 Jan 25.
3
Adipocyte extracellular vesicles carry enzymes and fatty acids that stimulate mitochondrial metabolism and remodeling in tumor cells.
Cells. 2024 Aug 1;13(15):1298. doi: 10.3390/cells13151298.
4
Prospects and challenges of tissue-derived extracellular vesicles.组织来源细胞外囊泡的前景与挑战。
Mol Ther. 2024 Sep 4;32(9):2950-2978. doi: 10.1016/j.ymthe.2024.06.025. Epub 2024 Jun 22.
5
Endotheliopathy in the metabolic syndrome: Mechanisms and clinical implications.代谢综合征中的血管内皮病变：机制与临床意义。
Pharmacol Ther. 2023 Apr;244:108372. doi: 10.1016/j.pharmthera.2023.108372. Epub 2023 Mar 7.
脂肪细胞外囊泡携带能刺激肿瘤细胞线粒体代谢和重塑的酶和脂肪酸。
EMBO J. 2020 Feb 3;39(3):e102525. doi: 10.15252/embj.2019102525. Epub 2020 Jan 10.
4
The many functions of ESCRTs.ESCRTs 的多种功能。
Nat Rev Mol Cell Biol. 2020 Jan;21(1):25-42. doi: 10.1038/s41580-019-0177-4. Epub 2019 Nov 8.
5
Extracellular Vesicles: Catching the Light in Zebrafish.细胞外囊泡：在斑马鱼中捕捉光明。
Trends Cell Biol. 2019 Oct;29(10):770-776. doi: 10.1016/j.tcb.2019.07.007. Epub 2019 Aug 7.
6
Mature Human White Adipocytes Cultured under Membranes Maintain Identity, Function, and Can Transdifferentiate into Brown-like Adipocytes.在膜下培养的成熟人类白色脂肪细胞可保持其特性、功能，并可转分化为棕色样脂肪细胞。
Cell Rep. 2019 Apr 2;27(1):213-225.e5. doi: 10.1016/j.celrep.2019.03.026.
7
Extracellular vesicle-based therapeutics: natural versus engineered targeting and trafficking.基于细胞外囊泡的治疗方法：天然与工程靶向和运输。
Exp Mol Med. 2019 Mar 15;51(3):1-12. doi: 10.1038/s12276-019-0223-5.
8
A lipase-independent pathway of lipid release and immune modulation by adipocytes.脂肪细胞通过非脂肪酶依赖途径释放脂质和调节免疫。
Science. 2019 Mar 1;363(6430):989-993. doi: 10.1126/science.aaw2586.
9
A transgenic inducible GFP extracellular-vesicle reporter (TIGER) mouse illuminates neonatal cortical astrocytes as a source of immunomodulatory extracellular vesicles.一种转基因诱导型 GFP 细胞外囊泡报告基因（TIGER）小鼠照亮了新生皮质星形胶质细胞，作为免疫调节细胞外囊泡的来源。
Sci Rep. 2019 Feb 28;9(1):3094. doi: 10.1038/s41598-019-39679-0.
10
An Endothelial-to-Adipocyte Extracellular Vesicle Axis Governed by Metabolic State.代谢状态调控的内皮细胞-脂肪细胞细胞外囊泡轴
Cell. 2018 Oct 18;175(3):695-708.e13. doi: 10.1016/j.cell.2018.09.005. Epub 2018 Oct 4.