College of Marine and Environmental Sciences, Tianjin University of Science and Technology, Tianjin 300457, China.
Protein Pept Lett. 2022;29(8):641-650. doi: 10.2174/0929866529666220613102145.
In recent years, the antibiotic resistance of pathogenic bacteria has become an increasing public health threat. Finding alternatives to antibiotics may be an effective solution to the problem of drug resistance. Antimicrobial peptides are small peptides produced by various organisms that are considered to be effective antibiotic substitutes because of their strong, broad-spectrum antibacterial activity, stability, and diversity, and because target strains do not easily develop resistance. Recent research on antimicrobial peptides has shown they have broad potential for applications in medicine, agriculture, food, and animal feed. The source, classification, acquisition methods, and mechanisms of action of antimicrobial peptides are very complex. This review presents an overview of research on the sources, isolation, expression and purification, and classification of antimicrobial peptides; the relationship between their structural conformation and function; their mechanisms of action; and application prospects.
近年来，病原菌的抗生素耐药性成为日益严重的公共卫生威胁。寻找抗生素替代品可能是解决耐药性问题的有效方法。抗菌肽是各种生物体产生的小肽，由于其强大、广谱的抗菌活性、稳定性和多样性，以及目标菌株不易产生耐药性，被认为是有效的抗生素替代品。最近对抗菌肽的研究表明，它们在医学、农业、食品和动物饲料方面具有广泛的应用潜力。抗菌肽的来源、分类、获取方法和作用机制非常复杂。本文综述了抗菌肽的来源、分离、表达和纯化、分类；它们的结构构象与功能之间的关系；它们的作用机制；以及应用前景。
