Pfeiffer P, Rauschen I, Bujanowski J, König W
Int Arch Allergy Appl Immunol. 1987;82(3-4):408-10. doi: 10.1159/000234240.
Generation of IgE-specific suppressor factors in vitro upon stimulation of murine lymphocytes with IgE was studied. High-molecular weight factors (greater than 50 kilodalton) suppressed in vivo IgE response as well as de novo IgE synthesis in vitro. Further, suppression of IgE synthesis in vitro by fractions of low molecular weight supernatants absorbed with IgE-Sepharose was obtained, suggesting a potent role for IgE binding factors in IgE synthesis.
研究了用IgE刺激鼠淋巴细胞后体外产生IgE特异性抑制因子的情况。高分子量因子(大于50千道尔顿)可抑制体内IgE反应以及体外新生IgE的合成。此外,用IgE-琼脂糖吸附的低分子量上清液组分可在体外抑制IgE合成,这表明IgE结合因子在IgE合成中发挥着重要作用。