Department of Urology, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY.
Department of Urology, McGill University, Montreal, Canada.
Urology. 2022 Oct;168:3-9. doi: 10.1016/j.urology.2022.05.036. Epub 2022 Jun 12.
The inability to conceive due to male infertility is a complex issue with a wide variety of etiologies. Sperm DNA damage can be both a barrier to natural pregnancy and successful assisted reproductive technology (ART). The aim of this narrative review was to describe and highlight the effects of sperm DNA fragmentation and the most recent data on various treatment strategies to decrease sperm DNA damage. Finally, we proposed a management algorithm for couples undergoing ART with increased sperm DNA fragmentation.
由于男性不育而无法受孕是一个复杂的问题，其病因多种多样。精子 DNA 损伤既可以成为自然妊娠和辅助生殖技术（ART）成功的障碍。本叙述性综述的目的是描述和强调精子 DNA 碎片化的影响，以及关于降低精子 DNA 损伤的各种治疗策略的最新数据。最后，我们为接受 ART 且精子 DNA 碎片化增加的夫妇提出了一种管理算法。
