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饮食中添加蜂花粉会影响斑马鱼肠道微生物群落组成，并促进皮肤黑色素瘤的发生。

Bee pollen in zebrafish diet affects intestinal microbiota composition and skin cutaneous melanoma development.

机构信息

Programa de Pós-graduação em Ciências Veterinárias-FZMV, Universidade Federal de Lavras, UFLA, 3037, Lavras, MG, 37200-900, Brasil.

Departamento de Biología Celular e Histología, Facultad de Biología, Universidad de Murcia. IMIB-Arrixaca. CIBERER, 30100, Murcia, Spain.

出版信息

Sci Rep. 2022 Jun 15;12(1):9998. doi: 10.1038/s41598-022-14245-3.

DOI:10.1038/s41598-022-14245-3
PMID:35705722
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9200724/
Abstract

Bee pollen is recommended as dietary supplement due to immunostimulating functions including antioxidant, anti-inflammatory and anti-carcinogenic properties. Nevertheless, the effectiveness of such properties is still not well understood. As diet can be associated with animal performance, microbiota modulation and potentially factor for cancer, this study aimed to analyze if bee pollen could influence growth, gut microbial and skin cutaneous melanoma development in zebrafish. Control diets based on commercial flakes and Artemia were compared with the same diet supplemented with bee pollen. Fish weight gain, increased length, intestinal bacteria metagenomics analysis, serum amyloid A gene expression and cutaneous melanoma transplantation assays were performed. Bee pollen affected microbiota composition and melanoma development. Differential abundance revealed higher abundance in the control group for Aeromonadaceae family, Aeromonas and Pseudomonas genus, A. sobria, A. schubertii, A. jandaei and P. alcaligenes species compared with pollen diet group. Pollen group presented higher abundance for Chromobacterium genus and for Gemmobacter aquaticus, Flavobacterium succinicans and Bifidobacterium breve compared with control group. Unexpectedly, fish fed with bee pollen showed higher tumor growth rate and larger tumor size than control group. This is the first study to report intestinal microbial changes and no protective cancer properties after bee pollen administration.

摘要

由于具有免疫刺激功能，包括抗氧化、抗炎和抗癌特性，蜂花粉被推荐作为膳食补充剂。然而，这些特性的有效性仍未得到很好的理解。由于饮食可能与动物性能、微生物群调节和癌症的潜在因素有关，本研究旨在分析蜂花粉是否会影响斑马鱼的生长、肠道微生物和皮肤皮肤黑色素瘤的发展。以商业薄片和丰年虾为基础的对照饮食与补充蜂花粉的相同饮食进行了比较。进行了鱼体重增加、体长增加、肠道细菌宏基因组分析、血清淀粉样蛋白 A 基因表达和皮肤黑色素瘤移植试验。蜂花粉影响了微生物群的组成和黑色素瘤的发展。差异丰度显示，与花粉饮食组相比，对照组中 Aeromonadaceae 科、气单胞菌属和假单胞菌属、A. sobria、A. schubertii、A. jandaei 和 P. alcaligenes 种的丰度更高。花粉组中 Chromobacterium 属和水生 Gemmobacter、Flavobacterium succinicans 和 Bifidobacterium breve 的丰度高于对照组。出乎意料的是，与对照组相比，喂食蜂花粉的鱼显示出更高的肿瘤生长速度和更大的肿瘤大小。这是第一项报道蜂花粉给药后肠道微生物变化和无保护癌症特性的研究。

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