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胚胎导管加载技术对妊娠率的影响。

The effect of embryo catheter loading technique on pregnancy rate.

机构信息

Department of Obstetrics and Gynecology, The Jones Institute for Reproductive Medicine, Eastern Virginia Medical School, Norfolk, Virginia, USA.

出版信息

Reprod Fertil. 2022 May 3;3(2):103-109. doi: 10.1530/RAF-22-0006. eCollection 2022 Apr 1.

DOI:10.1530/RAF-22-0006
PMID:35706582
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9175598/
Abstract

Embryo transfer is the most emotional part for patients during fertilization treatment. Over the last decade, the embryo transfer procedure has undergone numerous changes in the guidelines in order to increase pregnancy rates. One such procedure is the loading of the embryo into the catheter, a thin tube that helps us transfer embryo into the uterine cavity. Very few research studies looked closely at embryo-loading technique per se. Furthermore, different infertility laboratories use various techniques to load embryo. The aim of our study was to compare the two most popular embryo-loading techniques. In 249 women, we transferred embryo aspirated into the catheter with small droplets of air, and in the group of 244 patients, we filled catheter only with fluid. Our main outcome measured was the clinical pregnancy rate. Based on our results, we did not find that embryo-loading technique affected patient's chances of achieving pregnancy.

摘要

胚胎移植是患者在受精治疗过程中最情绪化的部分。在过去的十年中,胚胎移植程序在指南中发生了许多变化,以提高妊娠率。其中一种程序是将胚胎装入导管,这是一种帮助我们将胚胎转移到子宫腔的细管。很少有研究仔细研究胚胎装载技术本身。此外,不同的不孕不育实验室使用不同的技术来装载胚胎。我们的研究目的是比较两种最流行的胚胎装载技术。在 249 名女性中,我们将吸入导管中的胚胎与少量空气滴一起转移,在 244 名患者组中,我们仅用液体填充导管。我们测量的主要结果是临床妊娠率。根据我们的结果,我们没有发现胚胎装载技术会影响患者怀孕的机会。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/618a/9175598/f8b3bffbd118/RAF-22-0006fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/618a/9175598/3807fa697c32/RAF-22-0006fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/618a/9175598/f8b3bffbd118/RAF-22-0006fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/618a/9175598/3807fa697c32/RAF-22-0006fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/618a/9175598/f8b3bffbd118/RAF-22-0006fig2.jpg

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引用本文的文献

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Large-scale retrospective analysis of methodological factors affecting pregnancy rates after embryo transfer for in vitro fertilization.大规模回顾性分析影响体外受精胚胎移植后妊娠率的方法学因素。
Medicine (Baltimore). 2023 Sep 8;102(36):e35146. doi: 10.1097/MD.0000000000035146.

本文引用的文献

1
Does EmbryoGlue transfer medium affect embryo transfer success rate?胚胎黏附移植培养基会影响胚胎移植成功率吗?
Ceska Gynekol. 2018 Winter;83(3):177-181.
2
Low oxygen tension promotes invasive ability and embryo implantation rate.低氧张力可促进侵袭能力和胚胎着床率。
Reprod Biol. 2018 Sep;18(3):295-300. doi: 10.1016/j.repbio.2018.05.003. Epub 2018 Jun 5.
3
Low versus high volume of culture medium during embryo transfer: a randomized clinical trial.移植胚胎时使用低体积还是高体积的培养基:一项随机临床试验。
J Assist Reprod Genet. 2018 Apr;35(4):693-699. doi: 10.1007/s10815-017-1099-8. Epub 2017 Dec 12.
4
Performing the embryo transfer: a guideline.胚胎移植操作指南
Fertil Steril. 2017 Apr;107(4):882-896. doi: 10.1016/j.fertnstert.2017.01.025.
5
Guidance on the limits to the number of embryos to transfer: a committee opinion.胚胎移植数量限制指南:委员会意见
Fertil Steril. 2017 Apr;107(4):901-903. doi: 10.1016/j.fertnstert.2017.02.107. Epub 2017 Mar 11.
6
How do laboratory embryo transfer techniques affect IVF outcomes? A review of current literature.实验室胚胎移植技术如何影响体外受精的结果?当前文献综述。
Hum Fertil (Camb). 2017 Apr;20(1):3-13. doi: 10.1080/14647273.2016.1255357. Epub 2016 Nov 15.
7
Importance of embryo transfer technique in maximizing assisted reproductive outcomes.胚胎移植技术对于最大化辅助生殖效果的重要性。
Fertil Steril. 2016 Apr;105(4):855-60. doi: 10.1016/j.fertnstert.2016.02.022.
8
The effect of embryo catheter loading technique on the live birth rate.胚胎导管装载技术对活产率的影响。
Clin Exp Reprod Med. 2015 Dec;42(4):175-80. doi: 10.5653/cerm.2015.42.4.175. Epub 2015 Dec 31.
9
Embryo catheter loading and embryo culture techniques: results of a worldwide Web-based survey.胚胎导管装载与胚胎培养技术:一项基于全球网络调查的结果
J Assist Reprod Genet. 2014 Aug;31(8):1029-36. doi: 10.1007/s10815-014-0250-z. Epub 2014 Jun 10.
10
Impact of different embryo loading techniques on pregnancy rates in in vitro fertlization/embryo transfer cycles.不同胚胎装载技术对体外受精/胚胎移植周期妊娠率的影响。
J Hum Reprod Sci. 2013 Jan;6(1):65-9. doi: 10.4103/0974-1208.112385.