丙戊酸钠在癫痫患者中的药代动力学：通过单剂量研究预测维持剂量 - Suppr

Suppr

超能文献

Pharmacokinetics of sodium valproate in epileptic patients: prediction of maintenance dosage by single-dose study.

作者信息

Schapel G J, Beran R G, Doecke C J, O'Reilly W J, Reece P A, Rischbieth R H, Sansom L N, Stanley P E

出版信息

Eur J Clin Pharmacol. 1980 Jan;17(1):71-7. doi: 10.1007/BF00561679.

DOI:10.1007/BF00561679

PMID:6768573

Abstract

摘要

相似文献

Pharmacokinetics of sodium valproate in epileptic patients: prediction of maintenance dosage by single-dose study.丙戊酸钠在癫痫患者中的药代动力学：通过单剂量研究预测维持剂量

Eur J Clin Pharmacol. 1980 Jan;17(1):71-7. doi: 10.1007/BF00561679.

Pharmacokinetics of enteric-coated valproic acid.

Ther Drug Monit. 1984;6(1):21-3. doi: 10.1097/00007691-198403000-00005.

Steady-state valproate pharmacokinetics during long term therapy.

Clin Exp Neurol. 1983;19:183-91.

Intra-dose variation in plasma protein binding of sodium valproate in epileptic patients.癫痫患者中丙戊酸钠血浆蛋白结合的剂量内变异

Br J Clin Pharmacol. 1982 Sep;14(3):399-404. doi: 10.1111/j.1365-2125.1982.tb01998.x.

Single dose and steady state pharmacokinetics of valproic acid in adult epileptic patients.

Int J Clin Pharmacol Res. 1991;11(3):137-41.

Single and chronic dose pharmacokinetic studies of sodium valproate in epileptic patients.

Eur J Clin Pharmacol. 1979 Aug;16(1):23-9. doi: 10.1007/BF00644962.

[Correlation among sodium valproate concentrations in the total blood, plasma ultrafiltrate, and cerebrospinal fluid].

No To Hattatsu. 1983 Sep;15(5):390-5.

Comparison of sodium valproate and phenytoin as single drug treatment in epilepsy.丙戊酸钠与苯妥英钠作为癫痫单药治疗的比较。

Epilepsia. 1981 Feb;22(1):27-33. doi: 10.1111/j.1528-1157.1981.tb04330.x.

Comparison of steady-state pharmacokinetics of valproic acid in children between monotherapy and multiple antiepileptic drug treatment.

J Pediatr. 1985 Apr;106(4):653-8. doi: 10.1016/s0022-3476(85)80097-4.

[A study on cerebrospinal fluid and saliva to serum concentration ratios of anticonvulsants--Phenytoin, Phenobarbital, Valproic Acid and Primidone in epileptic patients].

Seishin Shinkeigaku Zasshi. 1982;84(9):661-79.

引用本文的文献

A population pharmacokinetic model taking into account protein binding for the sustained-release granule formulation of valproic acid in children with epilepsy.一个考虑蛋白质结合作用的丙戊酸缓释颗粒制剂在癫痫患儿中的群体药代动力学模型。

Eur J Clin Pharmacol. 2018 Jun;74(6):793-803. doi: 10.1007/s00228-018-2444-2. Epub 2018 Mar 21.

Optimisation of antiepileptic drug therapy. The importance of serum drug concentration monitoring.抗癫痫药物治疗的优化。血清药物浓度监测的重要性。

Clin Pharmacokinet. 1996 Aug;31(2):120-30. doi: 10.2165/00003088-199631020-00004.

Clinical pharmacokinetics of antiepileptic drugs in paediatric patients. Part I: Phenobarbital, primidone, valproic acid, ethosuximide and mesuximide.抗癫痫药物在儿科患者中的临床药代动力学。第一部分：苯巴比妥、扑米酮、丙戊酸、乙琥胺和甲琥胺。

Clin Pharmacokinet. 1995 Oct;29(4):257-86. doi: 10.2165/00003088-199529040-00005.

First-dose and steady-state pharmacokinetics of valproic acid in children with seizures.

Clin Pharmacokinet. 1983 Sep-Oct;8(5):447-55. doi: 10.2165/00003088-198308050-00005.

The effects of peritoneal dialysis on the single dose and steady state pharmacokinetics of valproic acid in a uremic epileptic child.

Eur J Clin Pharmacol. 1983;24(3):387-90. doi: 10.1007/BF00610060.

本文引用的文献

Blood levels of drug at the equilibrium state after multiple dosing.多次给药后达到平衡状态时药物的血药浓度。

Nature. 1965 Sep 18;207(5003):1301-2. doi: 10.1038/2071301a0.

Clinical and electroencephalographical classification of epileptic seizures.癫痫发作的临床和脑电图分类

Epilepsia. 1970 Mar;11(1):102-13. doi: 10.1111/j.1528-1157.1970.tb03871.x.

Principles for clinical testing of antiepileptic drugs.抗癫痫药物临床试验原则。

Epilepsia. 1973 Dec;14(4):451-8. doi: 10.1111/j.1528-1157.1973.tb03986.x.

Controlled trial of sodium valproate in severe epilepsy.丙戊酸钠治疗严重癫痫的对照试验。

Br Med J. 1975 Nov 1;4(5991):255-6. doi: 10.1136/bmj.4.5991.255.

Early experience with sodium valproate.丙戊酸钠的早期使用经验。

S Afr Med J. 1976 Nov 20;50(50):1997-8.

Sodium di-N-propylacetate (DPA) in the treatment of epilepsy. A review.二正丙基乙酸钠（DPA）治疗癫痫：综述

Epilepsia. 1975 Nov;16(4):549-73. doi: 10.1111/j.1528-1157.1975.tb04738.x.

Pharmacokinetics of di-n-propylacetate in epileptic patients.癫痫患者中丙二酸二正丙酯的药代动力学

Eur J Clin Pharmacol. 1975 Feb 28;8(2):97-105. doi: 10.1007/BF00561557.

Letter: Sodium valproate and platelet function.信件：丙戊酸钠与血小板功能。

Br Med J. 1976 Jul 17;2(6028):179. doi: 10.1136/bmj.2.6028.179-a.

The anticonvulsant action of sodium valproate (Epilim) in 100 patients with various forms of epilepsy.丙戊酸钠（德巴金）对100例不同类型癫痫患者的抗惊厥作用。

Med J Aust. 1977 Jun 18;1(25):911-5. doi: 10.5694/j.1326-5377.1977.tb131243.x.

Steady-state kinetics of valproic acid in epileptic patients.丙戊酸在癫痫患者中的稳态动力学

Clin Pharmacol Ther. 1978 Sep;24(3):324-32. doi: 10.1002/cpt1978243324.

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验