Amra Babak, Shafiei Amin, Soltaninejad Forogh, Asgari Abdollah, Farajzadegan Ziba
Department of Internal Medicine, Bamdad Respiratory and Sleep Research Center, Pulmonary Unit, Isfahan University of Medical Sciences, Isfahan, Iran.
Department of Internal Medicine, Medical School, Isfahan University of Medical Sciences, Isfahan, Iran.
Int J Prev Med. 2022 Apr 27;13:76. doi: 10.4103/ijpvm.IJPVM_602_20. eCollection 2022.
There was the association between the metabolic syndrome (MS) and obstructive sleep apnea (OSA). Also, the genetic factors have been implicated in the OSA. Our aim was to compare the frequency of MS in first-degree relatives (FDRs) of OSA patients with healthy controls.
39 FDR (parents, siblings, and children) of patients diagnosed with OSA at Bamdad Respiratory and Research Center as cases and age- and sex-matched healthy controls were included in the current case-control pilot study. The sampling method was convenience sampling based on having inclusion criteria and consent to participate in the study. Demographic characteristics and essential criteria for diagnosing MS included blood pressure, anthropometric [weight (kg), height (cm), waist circumference (cm) and body mass index (BMI) (kg/m)], and biochemical indices (lipid profile and blood glucose) were assessed based on standard protocols.
In the comparison of the demographic and clinical characteristics of two39 cases and control groups, weight and diastolic blood pressure were significantly higher in case group than controls ( < 0.05). Case and control groups were not significantly different in the frequency of MS ( > 0.05). Although, the frequency of hypertension as an important cardiovascular risk factor was higher in cases than controls ( < 0.05).
The present study demonstrates that the frequency of MS is not significantly different between FDRs of OSA patients and controls. However, further large-scale studies are warranted to detect the frequency of MS in people with hereditary background for OSA compared to general population.
代谢综合征（MS）与阻塞性睡眠呼吸暂停（OSA）之间存在关联。此外，遗传因素也与OSA有关。我们的目的是比较OSA患者的一级亲属（FDRs）与健康对照者中MS的发生率。
本病例对照试点研究纳入了39名在Bamdad呼吸与研究中心被诊断为OSA的患者的FDR（父母、兄弟姐妹和子女）作为病例组，以及年龄和性别匹配的健康对照者。抽样方法是基于纳入标准和同意参与研究的便利抽样。根据标准方案评估人口统计学特征以及诊断MS的基本标准，包括血压、人体测量指标[体重（kg）、身高（cm）、腰围（cm）和体重指数（BMI）（kg/m²）]和生化指标（血脂谱和血糖）。
在比较39例病例组和对照组的人口统计学和临床特征时，病例组的体重和舒张压显著高于对照组（P<0.05）。病例组和对照组在MS发生率上无显著差异（P>0.05）。尽管如此，作为重要心血管危险因素的高血压发生率在病例组中高于对照组（P<0.05）。
本研究表明，OSA患者的FDRs与对照组之间MS的发生率无显著差异。然而，有必要进行进一步的大规模研究，以检测与普通人群相比，具有OSA遗传背景的人群中MS的发生率。
