Rao N A, Sevanian A, Fernandez M A, Romero J L, Faure J P, de Kozak Y, Till G O, Marak G E
Invest Ophthalmol Vis Sci. 1987 May;28(5):886-92.
The experimental autoimmune disease elicited by a large dose of retinal S antigen in guinea pigs is characterized by massive necrotizing uveitis and retinitis. Treatment of these animals with the antioxidants superoxide dismutase, catalase, and sodium benzoate resulted in marked reduction of uveal inflammation. The attenuated inflammation was characterized by a relatively well-preserved retina and retinal pigment epithelium along with a reduction of subretinal exudate and vitreous inflammation. These findings suggest that reactive oxygen metabolites may play a role in the destruction of ocular tissue and amplification of the inflammatory process in experimental uveitis.
大剂量视网膜S抗原诱发的豚鼠实验性自身免疫疾病的特征是大规模坏死性葡萄膜炎和视网膜炎。用抗氧化剂超氧化物歧化酶、过氧化氢酶和苯甲酸钠治疗这些动物，可使葡萄膜炎症明显减轻。炎症减轻的特征是视网膜和视网膜色素上皮相对保存完好，同时视网膜下渗出物和玻璃体炎症减少。这些发现表明，活性氧代谢产物可能在实验性葡萄膜炎的眼组织破坏和炎症过程放大中起作用。
