Faure J P, Phuc L H, Takano S, Sterkers M, Thillaye B, de Kozak Y
J Fr Ophtalmol. 1981;4(6-7):465-72.
S antigen was isolated from human and bovine retinas and purified by two chromatographic steps. Its purity was controlled by SDS-electrophoresis and immunodiffusion. Seven Cynomolgus monkeys received a single subcutaneous immunization with either 50 or 100 micrograms of human S antigen (5 animals) or 100 micrograms of bovine S antigen (2 animals) with complete Freund's adjuvant. All the monkeys had bilateral uveoretinitis and anti-"S" antibodies were found in their serum. The time course of the disease was followed clinically during one year and pathologic features were described at various time intervals. The disease includes prominent retinal vasculitis and granulomatous chorio-retinitis, with a chronic course, and leads after many months to almost complete destruction of the retina, with persistence of inflammatory infiltrates and pigment of cell migration.
S抗原从人及牛视网膜中分离出来，并通过两步色谱法进行纯化。其纯度通过SDS电泳和免疫扩散进行检测。七只食蟹猴分别皮下注射50或100微克人S抗原（5只动物）或100微克牛S抗原（2只动物），并佐以完全弗氏佐剂。所有猴子均出现双侧葡萄膜视网膜炎，血清中检测到抗“S”抗体。临床随访该疾病病程一年，并在不同时间间隔描述病理特征。该疾病包括显著的视网膜血管炎和肉芽肿性脉络膜视网膜炎，病程呈慢性，数月后导致视网膜几乎完全破坏，炎症浸润和细胞迁移色素持续存在。
