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遭受低剂量辐射的原子弹幸存者的剂量反应分析。

Dose-response analyses among atomic bomb survivors exposed to low-level radiation.

作者信息

Kato H, Schull W J, Awa A, Akiyama M, Otake M

出版信息

Health Phys. 1987 May;52(5):645-52. doi: 10.1097/00004032-198705000-00017.

DOI:10.1097/00004032-198705000-00017
PMID:3570802
Abstract

An analysis of the dose response within the low-dose range (as here defined, doses of less than 50 cGy (50 rad) was conducted among A-bomb survivors in the ABCC-RERF cohort in an attempt to detect the phenomenon of radiation hormesis, if it is present. These studies include as endpoints cancer mortality, cancer incidence, the frequency of cells with chromosomal aberrations, the phytohemagglutinin response of peripheral lymphocytes and the frequency of mental retardation among survivors exposed in utero. In general, the dose response for these indices of radiation damage varied among comparison groups within the low-dose range, but failed to suggest the existence of radiation hormesis.

摘要

为了检测辐射兴奋效应现象(如果存在的话),对ABCC-RERF队列中的原子弹幸存者进行了低剂量范围(如本文所定义,剂量小于50 cGy(50拉德))内的剂量反应分析。这些研究包括癌症死亡率、癌症发病率、染色体畸变细胞频率、外周淋巴细胞的植物血凝素反应以及子宫内受照幸存者的智力迟钝频率等终点指标。总体而言,这些辐射损伤指标的剂量反应在低剂量范围内的各比较组之间有所不同,但未表明存在辐射兴奋效应。

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