Zhao Ziyi, Ji Hongxiang, Liu Wenyu, Wang Zhengdan, Ren Shengquan, Liu Chunlei, Wu Caifeng, Wang Jian, Ding Xiaoheng
Department of Hand and Foot, Microsurgery, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.
The First Clinical Medical College, Shandong University of Traditional Chinese Medicine, Jinan, Shandong, China.
PLoS One. 2025 Jun 2;20(6):e0324160. doi: 10.1371/journal.pone.0324160. eCollection 2025.
Many studies have demonstrated that obesity is closely linked with bone metabolism. A body shape index (ABSI) is a newly developed obesity indicator, which provides superior reflection of central obesity compared to body mass index (BMI) and waist circumference. Nevertheless, investigation of the association between ABSI and bone mineral density (BMD) remains limited. Thus, this study aimed to evaluate the correlation between ABSI and lumbar BMD among US adults.
We analyzed data of adults aged 20 years and older from 2011-2018 National Health and Nutrition Examination Survey. Weighted multiple regression analysis was conducted to assess the linear relationship between ABSI and lumbar BMD. Weighted smooth curve fitting and two-segment linear model were applied to explore the nonlinear association. Subgroup analysis stratified by age, gender, race, and BMI was performed.
A total of 10991 subjects was enrolled in the study. In the fully adjusted model, the ABSI was negatively related to lumbar BMD (β = -0.007, 95% CI: -0.009, -0.005). The adverse correlation remained significant across all subgroups among stratified analysis. The saturation effect between ABSI and lumbar BMD was identified, with the turning point at the ABSI value of 0.08. Similar nonlinear trends were also observed in participants aged <40 years, males, Non-Hispanic White, BMI < 25 kg/m2, and BMI ≥ 30 kg/m2.
This study revealed a prominently negative correlation and saturation effect between ABSI and lumbar BMD in US adults. Our findings may provide valuable inspiration for further prevention and intervention of osteoporosis.
许多研究表明，肥胖与骨代谢密切相关。体型指数（ABSI）是一种新开发的肥胖指标，与体重指数（BMI）和腰围相比，它能更好地反映中心性肥胖。然而，关于ABSI与骨密度（BMD）之间关联的研究仍然有限。因此，本研究旨在评估美国成年人中ABSI与腰椎骨密度之间的相关性。
我们分析了2011 - 2018年全国健康与营养检查调查中20岁及以上成年人的数据。进行加权多元回归分析以评估ABSI与腰椎骨密度之间的线性关系。应用加权平滑曲线拟合和两段线性模型来探索非线性关联。按年龄、性别、种族和BMI进行亚组分析。
共有10991名受试者纳入研究。在完全调整模型中，ABSI与腰椎骨密度呈负相关（β = -0.007，95%CI：-0.009，-0.005）。在分层分析的所有亚组中，这种负相关仍然显著。确定了ABSI与腰椎骨密度之间的饱和效应，转折点的ABSI值为0.08。在年龄<40岁的参与者、男性、非西班牙裔白人、BMI < 25 kg/m²和BMI≥30 kg/m²的人群中也观察到了类似的非线性趋势。
本研究揭示了美国成年人中ABSI与腰椎骨密度之间存在显著的负相关和饱和效应。我们的研究结果可能为进一步预防和干预骨质疏松症提供有价值的启示。
