Department of Environmental Sciences and Engineering, Gillings School of Global Public Health, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
The Institute for Environmental Health Solutions, Gillings School of Global Public Health, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
J Expo Sci Environ Epidemiol. 2022 Nov;32(6):794-807. doi: 10.1038/s41370-022-00451-8. Epub 2022 Jun 16.
Although evidence linking environmental chemicals to breast cancer is growing, mixtures-based exposure evaluations are lacking.
This study aimed to identify environmental chemicals in use inventories that co-occur and share properties with chemicals that have association with breast cancer, highlighting exposure combinations that may alter disease risk.
The occurrence of chemicals within chemical use categories was characterized using the Chemical and Products Database. Co-exposure patterns were evaluated for chemicals that have an association with breast cancer (BC), no known association (NBC), and understudied chemicals (UC) identified through query of the Silent Spring Institute's Mammary Carcinogens Review Database and the U.S. Environmental Protection Agency's Toxicity Reference Database. UCs were ranked based on structure and physicochemical similarities and co-occurrence patterns with BCs within environmentally relevant exposure sources.
A total of 6793 chemicals had data available for exposure source occurrence analyses. 50 top-ranking UCs spanning five clusters of co-occurring chemicals were prioritized, based on shared properties with co-occuring BCs, including chemicals used in food production and consumer/personal care products, as well as potential endocrine system modulators.
Results highlight important co-exposure conditions that are likely prevalent within our everyday environments that warrant further evaluation for possible breast cancer risk.
Most environmental studies on breast cancer have focused on evaluating relationships between individual, well-known chemicals and breast cancer risk. This study set out to expand this research field by identifying understudied chemicals and mixtures that may occur in everyday environments due to their patterns of commercial use. Analyses focused on those that co-occur alongside chemicals associated with breast cancer, based upon in silico chemical database querying and analysis. Particularly in instances when understudied chemicals share physicochemical properties and structural features with carcinogens, these chemical mixtures represent conditions that should be studied in future clinical, epidemiological, and toxicological studies.
尽管越来越多的证据表明环境化学物质与乳腺癌之间存在关联，但目前缺乏基于混合物的暴露评估方法。
本研究旨在确定在化学品使用清单中发现的与乳腺癌相关的化学物质，这些化学物质共同出现并具有相似的特性，突出可能改变疾病风险的暴露组合。
使用化学品和产品数据库（Chemical and Products Database）对化学品使用类别中的化学物质进行特征描述。通过查询 Silent Spring Institute 的乳腺致癌物质审查数据库（Silent Spring Institute's Mammary Carcinogens Review Database）和美国环境保护署的毒性参考数据库（U.S. Environmental Protection Agency's Toxicity Reference Database），确定与乳腺癌（BC）相关、无已知关联（NBC）和研究较少的化学物质（UC），评估这些化学物质的共同暴露模式。根据结构和物理化学相似性以及与环境相关暴露源中 BC 的共同出现模式，对 UC 进行排名。
共有 6793 种化学物质的数据可用于暴露源发生分析。基于与共同出现的 BC 共享的特性，包括用于食品生产和消费者/个人护理产品的化学物质，以及潜在的内分泌系统调节剂，确定了五个共同出现的化学物质簇中的 50 种排名最高的 UC，这些化学物质是优先考虑的。
结果突出了我们日常生活环境中可能普遍存在的重要共同暴露条件，这些条件需要进一步评估可能的乳腺癌风险。
大多数关于乳腺癌的环境研究都集中在评估单个、知名化学物质与乳腺癌风险之间的关系上。本研究旨在通过识别日常生活环境中可能由于商业用途而出现的研究较少的化学物质和混合物，扩展这一研究领域。分析侧重于那些与乳腺癌相关的化学物质共同出现的化学物质，基于计算机化学数据库查询和分析。特别是在研究较少的化学物质与致癌物质具有物理化学性质和结构特征的情况下，这些化学混合物代表了在未来的临床、流行病学和毒理学研究中应研究的条件。
