Liang Ying, Shen Yang, Li Gaofei, Yuan Ye, Zhang Meng, Gao Jiayu
National Clinical Research Center for Mental Disorders, Peking University Sixth Hospital, Key Laboratory of Mental Health, Ministry of Health, Institute of Mental Health, Peking University, Beijing, China.
Department of Psychiatry, Beijing Hospital of Integrated Traditional Chinese and Western Medicine, Beijing, China.
Front Psychiatry. 2022 May 30;13:864951. doi: 10.3389/fpsyt.2022.864951. eCollection 2022.
Recent studies have indicated the critical influence of gut microbiota on the occurrence of obesity. There is a significant risk of obesity in people with schizophrenia. This work proposed that the disorder of gut microbiota in patients with schizophrenia was based on microbial enterotypes. Ninety-seven patients with schizophrenia and 69 matched health controls were eligible. The fresh feces of all the subjects were collected and used to complete 16S rRNA sequence. Statistical analysis was performed to identify the intestinal type of gut microbiota and analyze their potential effects on metabolic function. The patients with enterotype-P had a higher BMI than that of the others. Several differences in the gut microbes of enterotype-P were found between the patients and the controls. Proteobacteria and Firmicutes had significantly higher abundance in the patients' group with enterotype-P. The Bacteroidetes had higher abundance in health controls with enterotype-P. Different metabolic pathways of the microbiota with the enterotype-P were identified in the subjects categorized in different BMI intervals. The schizophrenia patients had a significantly higher BMI than that of health controls. The patients with enterotype-P had a higher BMI. Therefore, the enterotype-P might have a critical influence on a variety of metabolic pathways to disturb the metabolism of glucose and lipid in human body.
近期研究表明肠道微生物群对肥胖症的发生具有关键影响。精神分裂症患者存在显著的肥胖风险。这项研究提出，精神分裂症患者肠道微生物群的紊乱基于微生物肠型。97名精神分裂症患者和69名匹配的健康对照者符合条件。收集所有受试者的新鲜粪便并用于完成16S rRNA测序。进行统计分析以确定肠道微生物群的肠型，并分析它们对代谢功能的潜在影响。肠型P患者的体重指数高于其他患者。在患者和对照者之间发现了肠型P患者肠道微生物的若干差异。变形菌门和厚壁菌门在肠型P患者组中的丰度显著更高。拟杆菌门在肠型P健康对照者中的丰度更高。在不同体重指数区间分类的受试者中鉴定出了具有肠型P的微生物群的不同代谢途径。精神分裂症患者的体重指数显著高于健康对照者。肠型P患者的体重指数更高。因此，肠型P可能对多种代谢途径产生关键影响，从而扰乱人体的葡萄糖和脂质代谢。
