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斑马鱼作为研究神经退行性疾病和其他神经紊乱的病理机制的模式生物。

Zebrafish as a Model Organism for Studying Pathologic Mechanisms of Neurodegenerative Diseases and other Neural Disorders.

机构信息

Department of Basic Medicine, School of Nursing and Health, Qingdao Huanghai University, Qingdao, 266427, China.

出版信息

Cell Mol Neurobiol. 2023 Aug;43(6):2603-2620. doi: 10.1007/s10571-023-01340-w. Epub 2023 Apr 1.

Abstract

Zebrafish are widely considered an excellent vertebrate model for studying the pathogenesis of human diseases because of their transparency of embryonic development, easy breeding, high similarity with human genes, and easy gene manipulation. Previous studies have shown that zebrafish as a model organism provides an ideal operating platform for clarifying the pathological and molecular mechanisms of neurodegenerative diseases and related human diseases. This review mainly summarizes the achievements and prospects of zebrafish used as model organisms in the research of neurodegenerative diseases and other human diseases related to the nervous system in recent years. In the future study of human disease mechanisms, the application of the zebrafish model will continue to provide a valuable operating platform and technical support for investigating and finding better prevention and treatment of these diseases, which has broad application prospects and practical significance. Zebrafish models used in neurodegenerative diseases and other diseases related to the nervous system.

摘要

斑马鱼由于胚胎发育透明、繁殖容易、与人基因高度相似、基因操作简单,被广泛认为是研究人类疾病发病机制的优秀脊椎动物模型。已有研究表明,斑马鱼作为一种模式生物,为阐明神经退行性疾病及相关人类疾病的病理和分子机制提供了理想的操作平台。本文主要综述了近年来斑马鱼作为模式生物在神经退行性疾病及其他神经系统相关人类疾病研究中的成果和应用前景。在人类疾病机制的未来研究中,斑马鱼模型的应用将继续为研究和寻找这些疾病更好的预防和治疗方法提供有价值的操作平台和技术支持,具有广阔的应用前景和现实意义。

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