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采用毛细管气液色谱法测定生物流体中的氨溴索。

Assay of ambroxol in biological fluids by capillary gas-liquid chromatography.

作者信息

Schmid J

出版信息

J Chromatogr. 1987 Feb 20;414(1):65-75. doi: 10.1016/0378-4347(87)80025-7.

DOI:10.1016/0378-4347(87)80025-7
PMID:3571392
Abstract

A sensitive and rapid method for the determination of ambroxol in biological fluids is described. It comprises a single extraction step, derivatization and selective determination with capillary gas-liquid chromatography (in split-mode) and electron-capture detection. The limit of quantification in plasma is ca. 3 ng/ml. The method is applied to the pharmacokinetics of ambroxol in humans.

摘要

描述了一种测定生物流体中氨溴索的灵敏且快速的方法。该方法包括单一萃取步骤、衍生化以及采用毛细管气液色谱法（分流模式）和电子捕获检测进行选择性测定。血浆中的定量限约为3 ng/ml。该方法应用于氨溴索在人体中的药代动力学研究。

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