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Assay of bromhexine in human plasma by capillary gas--liquid chromatography with nitrogen-selective detection and selected ion monitoring.

作者信息

Schmid J, Koss F W

出版信息

J Chromatogr. 1982 Jan 8;227(1):71-81. doi: 10.1016/s0378-4347(00)80357-6.

DOI:10.1016/s0378-4347(00)80357-6
PMID:7056824
Abstract

A specific, sensitive method for the determination of bromhexine in human plasma is described. It comprises a selective extraction procedure and a specific determination with capillary gas--liquid chromatography and nitrogen-selective flame ionization detection. The detection limit of the assay is about 0.5 ng/ml. The specificity of the assay was checked by gas chromatography--mass spectrometry. The method is applied to the pharmacokinetics of bromhexine in humans.

摘要

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