Alberta Centre for Toxicology, Department of Physiology & Pharmacology, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
Alberta Centre for Toxicology, Department of Physiology & Pharmacology, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
Int J Hyg Environ Health. 2022 Jul;244:113990. doi: 10.1016/j.ijheh.2022.113990. Epub 2022 Jun 14.
The Alberta Biomonitoring Program (ABP) was created in 2005 with the initial goal of establishing baseline levels of exposure to environmental chemicals in specific populations in the province of Alberta, Canada, and was later expanded to include multiple phases. The first two phases focused on evaluating exposure in pregnant women (Phase One, 2005) and children (Phase Two, 2004-2006) by analyzing residual serum specimens. Phase Three (2013-2016) employed active recruitment techniques to evaluate environmental exposures using a revised list of chemicals in paired serum pools from pregnant women and umbilical cord blood. These three phases of the program monitored a total of 226 chemicals in 285 pooled serum samples representing 31,529 individuals. Phase Four (2017-2020) of the ABP has taken a more targeted approach, focusing on the impact of the federal legalization of cannabis on the exposure of pregnant women in Alberta to cannabis, as well as tobacco and alcohol using residual prenatal screening serum specimens. Chemicals monitored in the first three phases include herbicides, neutral pesticides, metals, metalloids, and micronutrients, methylmercury, organochlorine pesticides, organophosphate pesticides, parabens, phthalate metabolites, perfluoroalkyl substances (PFAS), phenols, phytoestrogens, polybrominated compounds, polychlorinated biphenyls (PCBs), dioxins and furans, polycyclic aromatic hydrocarbons (PAHs), and tobacco biomarkers. Phase Four monitored six biomarkers of tobacco, alcohol, and cannabis. All serum samples were pooled. Mean concentrations and 95% confidence intervals (CIs) were calculated for the chemicals detected in ≥25% of the sample pools. cross the first three phases, the data from the ABP has provided baseline exposure levels for the chemicals in pregnant women, children, and newborns across the province. Comparison within and among the phases has highlighted differences in exposure levels with age, geography, seasonality, sample type, and time. The strategies employed throughout the program phases have been demonstrated to provide effective models for population biomonitoring.
阿尔伯塔生物监测计划（ABP）于 2005 年成立，最初的目标是确定加拿大阿尔伯塔省特定人群中环境化学物质暴露的基线水平，并随后扩展到多个阶段。前两个阶段侧重于通过分析剩余血清样本评估孕妇（第一阶段，2005 年）和儿童（第二阶段，2004-2006 年）的暴露情况。第三阶段（2013-2016 年）采用了主动招募技术，使用来自孕妇和脐带血的配对血清池中的修订化学物质清单来评估环境暴露。该计划的三个阶段共监测了 285 个 pooled 血清样本中的 226 种化学物质，代表了 31529 个人。ABP 的第四阶段（2017-2020 年）采取了更具针对性的方法，重点关注联邦大麻合法化对阿尔伯塔省孕妇接触大麻以及烟草和酒精的影响，使用剩余的产前筛查血清样本。前三个阶段监测的化学物质包括除草剂、中性杀虫剂、金属、类金属和微量元素、甲基汞、有机氯杀虫剂、有机磷杀虫剂、对羟基苯甲酸酯、邻苯二甲酸代谢物、全氟烷基物质（PFAS）、酚类、植物雌激素、多溴化化合物、多氯联苯（PCBs）、二恶英和呋喃、多环芳烃（PAHs）和烟草生物标志物。第四阶段监测了烟草、酒精和大麻的六个生物标志物。所有血清样本均进行了混合。计算了≥25%样本池检测到的化学物质的浓度均值和 95%置信区间（CI）。纵观前三个阶段，ABP 的数据为全省孕妇、儿童和新生儿提供了化学物质的基线暴露水平。各阶段内和阶段间的比较突出了年龄、地理位置、季节性、样本类型和时间对暴露水平的影响。整个计划阶段采用的策略已被证明为人群生物监测提供了有效的模型。
