State Key Laboratory Breeding Base of Green Pesticide and Agricultural Bioengineering, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Guizhou University, Huaxi District, Guiyang 550025, China.
State Key Laboratory Breeding Base of Green Pesticide and Agricultural Bioengineering, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Guizhou University, Huaxi District, Guiyang 550025, China.
Pestic Biochem Physiol. 2022 Jun;184:105122. doi: 10.1016/j.pestbp.2022.105122. Epub 2022 May 15.
The discovery of new scaffolds and targets for pesticides is still a huge challenge facing the sustainable development of modern agriculture. In recent years, quinazoline derivatives have achieved great progress in drug discovery and have attracted great attention. Quinazoline is a unique bicyclic scaffold with a variety of biological activities, which increases the possibilities and flexibility of structural modification, showing enormous appeal in the discovery of new pesticides. Therefore, the agricultural biological activities, structure-activity relationships (SAR), and mechanism of action of quinazoline derivatives in the past decade were reviewed systematically, with emphasis on SAR and mechanism. Then, we prospected the application of the quinazoline scaffold as a special structure in agricultural chemical discovery, hoping to provide new ideas for the rational design and mechanism of novel quinazoline agricultural chemicals in the future.
新的农药支架和靶标的发现仍然是现代农业可持续发展面临的巨大挑战。近年来，喹唑啉衍生物在药物发现方面取得了巨大进展，引起了广泛关注。喹唑啉是一种独特的双环支架，具有多种生物活性，增加了结构修饰的可能性和灵活性，在新农药的发现中具有巨大的吸引力。因此，系统地综述了过去十年中喹唑啉衍生物在农业生物活性、构效关系（SAR）和作用机制方面的研究进展，重点介绍了 SAR 和作用机制。然后，我们展望了喹唑啉骨架作为特殊结构在农用化学品发现中的应用，希望为未来新型喹唑啉农用化学品的合理设计和作用机制提供新的思路。
