State Key Laboratory of Green Pesticide, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Center for R&D of Fine Chemicals of Guizhou University, Guiyang 550025, People's Republic of China.
J Agric Food Chem. 2024 Jun 5;72(22):12373-12386. doi: 10.1021/acs.jafc.4c01582. Epub 2024 May 22.
Finding highly active molecular scaffold structures is always the key research content of new pesticide discovery. In the research and development of new pesticides, the discovery of new agricultural molecular scaffold structures and new targets still faces great challenges. In recent years, quinoline derivatives have developed rapidly in the discovery of new agriculturally active molecules, especially in the discovery of fungicides. The unique quinoline scaffold has many advantages in the discovery of new pesticides and can provide innovative and feasible solutions for the discovery of new pesticides. Therefore, we reviewed the use of quinoline derivatives and their analogues as molecular scaffolds in the discovery of new pesticides since 2000. We systematically summarized the agricultural biological activity of quinoline compounds and discussed the structure-activity relationship (SAR), physiological and biochemical properties, and mechanism of action of the active compounds, hoping to provide ideas and inspiration for the discovery of new pesticides.
寻找高活性的分子骨架结构一直是新农药发现的关键研究内容。在新农药的研究与开发中，仍然面临着发现新的农业用分子骨架结构和新靶标的巨大挑战。近年来，在新农业活性分子的发现中，喹啉衍生物发展迅速，尤其是在杀菌剂的发现中。独特的喹啉骨架在新农药的发现中有许多优势，可以为新农药的发现提供创新性和可行性的解决方案。因此，我们综述了 2000 年以来以喹啉衍生物及其类似物作为分子骨架在新农药发现中的应用。我们系统地总结了喹啉类化合物的农业生物活性，并讨论了活性化合物的构效关系（SAR）、生理生化性质和作用机制，希望为新农药的发现提供思路和启示。
