Egoryan Goar, Yanez-Bello Maria A, Ozcekirdek Emre C, Zhang Qishuo, Poudel Bidhya, Ozen Ece, Trelles-Garcia Daniela P, Chung Chul Won, Ginsburg Beth, Friedman Harvey J, Rodriguez-Nava Guillermo
Department of Internal Medicine, AMITA Health Saint Francis Hospital, Evanston, IL.
Department of Internal Medicine, AMITA Health Saint Joseph Hospital, Chicago, IL.
IJID Reg. 2022 Jun;3:1-7. doi: 10.1016/j.ijregi.2022.02.001. Epub 2022 Feb 6.
To describe the clinical characteristics and outcomes of two waves of the COVID-19 pandemic.
A de-identified dataset of patients with COVID-19 admitted to our community hospital in Evanston, Illinois, from March 1, 2020 to February 28, 2021 was retrospectively reviewed. Patients from the first wave were identified as those admitted during the initial peak of admissions observed at our hospital between March 1, 2020 and September 3, 2020. The second wave was defined as those admitted during the second peak of admissions observed between October 1, 2020 and February 28, 2021.
In total, 671 patients were included. Of these, 399 (59.46%) were identified as patients from the first wave and 272 (40.54%) as patients from the second wave. Significantly more patients received steroids (86.4% vs 47.9%, < 0.001), remdesivir (59.6% vs 9.5%, < 0.001), humidified high-flow nasal cannula (18% vs 6.5%, < 0.001), and noninvasive ventilation (11.8% vs 3.3%, < 0.001) during the second wave. Patients from the first wave had a greater hazard for death compared with patients from the second wave (hazard ratio [HR] 1.62, 95% CI 1.08-2.43; = 0.019).
Among patients hospitalized with COVID-19 in our community hospital, there was a decrease in case-fatality rate in the second surge of the COVID-19 pandemic compared with the first wave.
描述新冠疫情两波疫情的临床特征和结果。
回顾性分析了2020年3月1日至2021年2月28日在伊利诺伊州埃文斯顿我们社区医院收治的新冠患者的去识别数据集。第一波患者被确定为在2020年3月1日至2020年9月3日我们医院观察到的入院初始高峰期间入院的患者。第二波被定义为在2020年10月1日至2021年2月28日观察到的入院第二个高峰期间入院的患者。
共纳入671例患者。其中，399例（59.46%）被确定为第一波患者，272例（40.54%）为第二波患者。在第二波疫情期间，接受类固醇治疗的患者显著增多（86.4%对47.9%，<0.001），瑞德西韦（59.6%对9.5%，<0.001），高流量湿化鼻导管吸氧（18%对6.5%，<0.001），以及无创通气（11.8%对3.3%，<0.001）。与第二波患者相比，第一波患者的死亡风险更高（风险比[HR]1.62，95%可信区间1.08 - 2.43；P = 0.019）。
在我们社区医院收治的新冠住院患者中，与第一波相比，新冠疫情第二波高峰时的病死率有所下降。
