摩洛哥市场上销售的抗酸剂的酸中和能力及其他特性评估。
Evaluation of the acid-neutralizing capacity and other properties of antacids marketed in Morocco.
作者信息
Yafout Mohamed, Elhorr Hicham, Otmani Ibrahim Sbai El, Khayati Youssef
机构信息
Laboratory of Drug Sciences, Biomedical Research and Biotechnology, Faculty of Medicine and Pharmacy Casablanca, Hassan II University, Casablanca, Morocco.
出版信息
Med Pharm Rep. 2022 Jan;95(1):80-87. doi: 10.15386/mpr-2082. Epub 2022 Jan 31.
AIM
The aim of this study was to evaluate the acid-neutralizing capacity (ANC) and other properties of antacid drugs marketed in Morocco.
METHODS
Samples of 12 antacids were collected from pharmacies and were subjected to the test described in the US Pharmacopoeia in order to measure their ANC. Other properties such as price and sodium content were also studied.
RESULTS
All the tested brands met the minimal requirement of 5 mEq. However, Aluminum hydroxide/Magnesium hydroxide combinations showed a superior acid-neutralizing capacity over other products and oral suspensions showed better results compared to other pharmaceutical forms. Regarding the cost of antacids, Aluminum hydroxide/Magnesium hydroxide combinations and calcium carbonate/magnesium carbonate combinations showed the most favorable ANC/price ratio. Some of the antacids studied contain a high amount of sodium.
CONCLUSION
All the antacids marketed in Morocco meet the USP requirement regarding their ANC. However, the ANC value should be included in the antacids' labels so that both patients and physicians can choose the most appropriate product. The ANC value should be evaluated according to the dose of the active substance instead of the minimum labeled dosage in order to allow a better result interpretation.
目的
本研究旨在评估在摩洛哥销售的抗酸药物的酸中和能力（ANC）及其他特性。
方法
从药店收集了12种抗酸剂样品，并按照美国药典中描述的测试方法来测定其ANC。还研究了其他特性，如价格和钠含量。
结果
所有测试品牌均符合5 mEq的最低要求。然而，氢氧化铝/氢氧化镁组合显示出比其他产品更高的酸中和能力，并且口服混悬液与其他剂型相比效果更佳。关于抗酸剂的成本，氢氧化铝/氢氧化镁组合和碳酸钙/碳酸镁组合显示出最有利的ANC/价格比。所研究的一些抗酸剂含有大量的钠。
结论
在摩洛哥销售的所有抗酸剂在ANC方面均符合美国药典要求。然而，ANC值应包含在抗酸剂标签中，以便患者和医生都能选择最合适的产品。应根据活性物质的剂量而非最低标注剂量来评估ANC值，以便能更好地解读结果。
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