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外泌体在肿瘤细胞与肿瘤微环境之间细胞通讯中的作用。

Role of exosomes in cellular communication between tumor cells and the tumor microenvironment.

作者信息

Li Qiao

机构信息

Department of Clinical Immunology, Tongji Hospital, Tongji Medical College, Huazhong University of Sciences and Technology, Wuhan, Hubei 430000, P.R. China.

出版信息

Oncol Lett. 2022 May 31;24(1):240. doi: 10.3892/ol.2022.13360. eCollection 2022 Jul.

DOI:10.3892/ol.2022.13360
PMID:35720493
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9185148/
Abstract

Exosomes are nanovesicles secreted by almost all types of cells. They contain RNAs, microRNAs, proteins and other bioactive substances, and can be used as carriers and for communication between cells. They regulate numerous biological processes, such as tumor development, cell proliferation and resistance to chemotherapy. Exosome-mediated communication between tumor cells and the tumor microenvironment (TME) is crucial in the initiation and progression of tumor development. The present review aims to summarize the role of exosomes in mediating the communication between tumor cells and the TME and to suggest the potential use of exosomes as targets for the development of novel therapeutic strategies against cancer.

摘要

外泌体是几乎所有类型细胞分泌的纳米囊泡。它们含有RNA、微小RNA、蛋白质和其他生物活性物质，可作为载体并用于细胞间通讯。它们调节众多生物学过程，如肿瘤发展、细胞增殖和化疗耐药性。肿瘤细胞与肿瘤微环境（TME）之间通过外泌体介导的通讯在肿瘤发生和发展过程中至关重要。本综述旨在总结外泌体在介导肿瘤细胞与TME通讯中的作用，并提出将外泌体作为开发新型抗癌治疗策略靶点的潜在用途。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cc09/9185148/0e3ef48838ce/ol-24-01-13360-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cc09/9185148/742dce73e6cd/ol-24-01-13360-g00.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cc09/9185148/0e3ef48838ce/ol-24-01-13360-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cc09/9185148/742dce73e6cd/ol-24-01-13360-g00.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cc09/9185148/0e3ef48838ce/ol-24-01-13360-g01.jpg

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本文引用的文献

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A Different Exosome Secretion Pattern Characterizes Patient-Derived Colorectal Cancer Multicellular Spheroids and Their Mouse Xenografts.不同的外泌体分泌模式是患者来源的结直肠癌多细胞球体及其小鼠异种移植瘤的特征。
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