Alzyoud Raed, Alsuwaiti Motasem, Maittah Hiba, Aladaileh Boshra, Nobani Mohammed, Farhan Ayman, Alqurieny Hadeel, Khatatbeh Ahmed, Habahbeh Zeyad
Allergy, Immunology, and Rheumatology, Queen Rania Children's Hospital, Amman, JOR.
Dentistry, Queen Rania Children's Hospital, Amman, JOR.
Cureus. 2022 Jun 11;14(6):e25841. doi: 10.7759/cureus.25841. eCollection 2022 Jun.
Objectives This study aims to describe the clinical, etiological, and treatment features of noninfectious uveitis in Jordanian children in a single center. Methods A retrospective, observational analysis of medical records of pediatric patients who were diagnosed with noninfectious uveitis from 2015 to 2020 at pediatric rheumatology and ophthalmology clinics at Queen Rania Children's Hospital, Amman, Jordan, was conducted. All patients were below 14 years of age at diagnosis. The collected data included age at diagnosis, anatomical location of uveitis, laterality, associated systemic disease, and used medications. Results Overall, 96 patients were included in this cohort (41 males and 55 females), with a mean age at diagnosis of 8.4±2.4 years. Anterior uveitis (44.8%) was the commonest anatomical location. Based on laterality, bilateral uveitis was reported in 59.3% of all patients. Idiopathic uveitis (46.9%) and juvenile idiopathic arthritis-associated uveitis (JIAU) (35.5%) were the most common diagnoses. Of the children with idiopathic uveitis, 47% had panuveitis, while 61.7% of the children with JIAU had chronic anterior uveitis. Posterior synechiae were the most common complication (12.5%). Patients with refractory uveitis received infliximab (29.1%) and adalimumab (4.1%). Conclusion To the best of our knowledge, this is the first report on noninfectious uveitis in Jordanian children. Compared with other regional and international published reports, JIAU and idiopathic uveitis were the most common diagnoses. To obtain more details on noninfectious uveitis characteristics, a population-based rather than a single-center study is needed in Jordan.
目的 本研究旨在描述约旦一家单中心儿童非感染性葡萄膜炎的临床、病因及治疗特征。方法 对2015年至2020年在约旦安曼王后拉尼亚儿童医院儿科风湿病科和眼科门诊诊断为非感染性葡萄膜炎的儿科患者病历进行回顾性观察分析。所有患者诊断时年龄均在14岁以下。收集的数据包括诊断时的年龄、葡萄膜炎的解剖位置、病变侧别、相关全身疾病及使用的药物。结果 本队列共纳入96例患者（41例男性和55例女性），诊断时的平均年龄为8.4±2.4岁。前葡萄膜炎（44.8%）是最常见的解剖位置。根据病变侧别，59.3%的患者为双侧葡萄膜炎。特发性葡萄膜炎（46.9%）和幼年特发性关节炎相关葡萄膜炎（JIAU）（35.5%）是最常见的诊断。在特发性葡萄膜炎患儿中，47%为全葡萄膜炎，而在JIAU患儿中，61.7%为慢性前葡萄膜炎。后粘连是最常见的并发症（12.5%）。难治性葡萄膜炎患者接受了英夫利昔单抗（29.1%）和阿达木单抗（4.1%）治疗。结论 据我们所知，这是关于约旦儿童非感染性葡萄膜炎的首份报告。与其他地区和国际发表的报告相比，JIAU和特发性葡萄膜炎是最常见的诊断。为获取更多关于非感染性葡萄膜炎特征的详细信息，约旦需要开展基于人群而非单中心的研究。
