Bevilacqua Gregorio, Zhang Jean, Parsons Camille, Laskou Faidra, Fuggle Nicholas, Cooper Cyrus, Dennison Elaine
MRC Lifecourse Epidemiology Centre, Southampton SO16 6YD, UK.
NIHR Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust, Southampton, UK.
EXCLI J. 2022 Apr 19;21:695-703. doi: 10.17179/excli2022-4874. eCollection 2022.
While there are many known health benefits to maintained physical activity levels in late adulthood, there have been very few studies that have considered relationships between morbidity profile and physical activity in the eighth decade of life. We studied 1097 participants, 555 men and 542 women from the Hertfordshire Cohort Study, a UK community based sample. Validated questionnaire based data were used to relate self-reported physical activity (PA) levels to medical history, and medication use. Regression analyses were adjusted for age, BMI, smoker status, alcohol consumption. The mean (SD) age of participants in the study was 80.2 (2.7) years for men and 80.2 (2.6) for women. A higher proportion of men (33.7 %) than women (24 %) were in the high activity score group. 20.8 % of female participants and 22.6 % male participants reported having no comorbid disease; 10.5 % men and 8.4 % women were taking no medication. Higher number of chronic conditions was associated with lower levels of PA [men (OR 0.73, 95 % CI 0.63-0.84, p<0.001); women (OR 0.74, 95 % CI 0.64-0.86, p<0.001)] as was being prescribed a higher number of medications [men (OR 0.88, 95 % CI 0.84-0.93, p<0.001); women (OR 0.86, 95 % CI 0.82-0.91, p<0.001)]. All these associations remained robust following adjustments. Strong relationships were seen in both sexes between PA and taking medication for disorders of the central nervous system and gastrointestinal system, with relationships generally stronger in men. We have observed relationships between comorbid medical history and medication use with physical activity in a cohort of community dwelling older adults. These highlight the need to consider medical history when considering how best to optimize PA in older adults.
虽然在成年晚期保持身体活动水平对健康有诸多益处，但很少有研究探讨过80岁人群的发病情况与身体活动之间的关系。我们对来自英国赫特福德郡队列研究的1097名参与者进行了研究，其中包括555名男性和542名女性，这是一个基于社区的样本。基于经过验证的问卷数据，将自我报告的身体活动（PA）水平与病史及药物使用情况相关联。回归分析对年龄、体重指数、吸烟状况、饮酒量进行了调整。研究中男性参与者的平均（标准差）年龄为80.2（2.7）岁，女性为80.2（2.6）岁。高活动得分组中男性的比例（33.7%）高于女性（24%）。20.8%的女性参与者和22.6%的男性参与者报告没有合并症；10.5%的男性和8.4%的女性未服用任何药物。慢性病数量较多与PA水平较低相关[男性（比值比0.73，95%置信区间0.63 - 0.84，p<0.001）；女性（比值比0.74，95%置信区间0.64 - 0.86，p<0.001）]，服用药物数量较多也与之相关[男性（比值比0.88，95%置信区间0.84 - 0.93，p<0.001）；女性（比值比0.86，95%置信区间0.82 - 0.91，p<0.001）]。经过调整后，所有这些关联仍然显著。在PA与服用治疗中枢神经系统和胃肠道疾病药物之间，男女两性均呈现出强烈的关系，且这种关系在男性中通常更强。我们在一组社区居住的老年人中观察到了合并症病史和药物使用与身体活动之间的关系。这些结果凸显了在考虑如何最好地优化老年人的PA时，需要考虑病史的必要性。
