Xu Jia, Lu Zhengyu, Zhang Hongjing, Shen Yan, Zhao Hong
VIP Department, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China.
Teaching Affairs Department, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200437, China.
Evid Based Complement Alternat Med. 2022 Jun 8;2022:6541600. doi: 10.1155/2022/6541600. eCollection 2022.
The aim of the study was to explore the regularity of acupoints in the treatment of amyotrophic lateral sclerosis (ALS) by means of data mining technology.
Nine databases, including SinoMed, Chongqing VIP (CQVIP), China National Knowledge Infrastructure (CNKI), Wanfang Data, Cochrane Library, PubMed, MEDLINE, Web of Science, and Embase, were comprehensively searched till December 2021. The published clinical literature testing acupuncture in the treatment of ALS was eligible for inclusion. Studies were organized to establish the prescription database. Modular data mining analysis, including acupoint frequency, complex network analysis, association rule analysis, and cluster analysis were used to conduct statistical analysis.
Forty-two literature studies on 141 acupoints were included, involving 626 times the total application frequency. The top 5 acupoints in application frequency were Hegu (LI 4, 67%), Zusanli (ST 36, 67%), Quchi (LI 11, 52%), Sanyinjiao (SP 6, 48%), and Yanglingquan (GB 34, 45%). The most involved meridian was the large intestine meridian of hand Yangming (90 times). The generally used acupoints were mainly distributed in the lower limbs. The top 5 combinations in application frequency were Hegu-Quchi (75 times), Quchi-Zusanli (66 times), Zusanli-Sanyinjiao (54 times), Hegu-Sanyinjiao (54 times), and Quchi-Sanyinjiao (49 times). The acupoint combinations with the strongest association were Quchi, Hegu, Zusanli, Sanyinjiao, and Shousanli (LI 10). There were 7 acupoint groups according to the cluster analysis. The core prescriptions were Hegu, Zusanli, Quchi, and Jiaji (EX-B 2).
Hegu, Zusanli, Quchi, and Jiaji could be used as the main prescriptions in treating ALS. The combination of Quchi, Hegu, Zusanli, and Sanyinjiao should be selected with priority in acupuncture therapy.
本研究旨在运用数据挖掘技术探索穴位治疗肌萎缩侧索硬化症（ALS）的规律。
全面检索了9个数据库，包括中国生物医学文献数据库（SinoMed）、重庆维普（CQVIP）、中国知网（CNKI）、万方数据、考克兰图书馆、PubMed、MEDLINE、Web of Science和Embase，检索截至2021年12月。纳入已发表的关于针刺治疗ALS的临床文献。整理研究建立方剂数据库。采用模块化数据挖掘分析，包括穴位频次、复杂网络分析、关联规则分析和聚类分析进行统计分析。
纳入42项关于141个穴位的文献研究，总应用频次达626次。应用频次排名前5位的穴位依次为合谷（LI 4，67%）、足三里（ST 36，67%）、曲池（LI 11，52%）、三阴交（SP 6，48%）、阳陵泉（GB 34，45%）。涉及最多的经络是手阳明大肠经（90次）。常用穴位主要分布在下肢。应用频次排名前5位的穴位组合依次为合谷-曲池（75次）、曲池-足三里（66次）、足三里-三阴交（54次）、合谷-三阴交（54次）、曲池-三阴交（49次）。关联性最强的穴位组合为曲池、合谷、足三里、三阴交和手三里（LI 10）。聚类分析得到7个穴位组。核心方剂为合谷、足三里、曲池和夹脊（EX-B 2）。
合谷、足三里、曲池和夹脊可作为治疗ALS的主要方剂。针刺治疗时应优先选择曲池、合谷、足三里和三阴交的组合。
