Wang Liaoyao, Xu Jia, Zhan Yijun, Pei Jian
Department of Acupuncture.
Special Wards, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Medicine (Baltimore). 2020 May 22;99(21):e20244. doi: 10.1097/MD.0000000000020244.
Alzheimer's disease (AD) is the fifth-leading cause of death in people more than 65 years old. Acupuncture therapy has been traditionally used to treat various kinds of health problems including AD. This protocol aims to summarize the available evidence from current systematic reviews (SRs) for the efficacy of acupuncture therapy for AD.
Seven databases will be searched: PubMed, Cochrane Library, Embase, China National Knowledge Infrastructure (CNKI), Wanfang Data, Chongqing VIP (CQVIP), and Chinese Biomedical Literature Database (CBM). SRs/meta-analyses (MAs) of acupuncture therapy for AD which were reported in Chinese or English will be included. Study selection, data extraction, and assessment of the study quality will be performed independently by 2 or more reviewers. And the methodological quality, report quality and evidence quality will be evaluated by Assessment of Multiple Systematic Reviews-2 (AMSTAR-2) tool, Preferred Reporting Items for Systematic Reviews and Meta Analyses Statement (PRISMA) checklist and Grading of Recommendations Assessment, Development and Evaluation (GRADE) system, respectively.
The article in this overview will be submitted for publication in a peer-reviewed journal.
We expect to compile evidence from multiple systematic reviews of acupuncture therapy in AD patients in an accessible and useful document.Registration number: INPLASY202040035.
阿尔茨海默病（AD）是65岁以上人群中第五大死因。传统上，针灸疗法用于治疗包括AD在内的各种健康问题。本方案旨在总结当前系统评价（SR）中关于针灸疗法治疗AD疗效的现有证据。
将检索七个数据库：PubMed、Cochrane图书馆、Embase、中国知网（CNKI）、万方数据、重庆维普（CQVIP）和中国生物医学文献数据库（CBM）。纳入以中文或英文报道的针灸疗法治疗AD的SR/荟萃分析（MA）。研究选择、数据提取和研究质量评估将由两名或更多评审员独立进行。方法学质量、报告质量和证据质量将分别通过多重系统评价评估-2（AMSTAR-2）工具、系统评价和荟萃分析报告规范（PRISMA）清单以及推荐分级评估、制定和评价（GRADE）系统进行评估。
本综述中的文章将提交给同行评审期刊发表。
我们期望在一份易于获取且有用的文件中汇编来自对AD患者针灸疗法的多个系统评价的证据。注册号：INPLASY202040035。
