Cai Yue, Zhao Yanqin, Kang Yongbo, Yang Ying
Department of Endocrinology, Affiliated Hospital of Yunnan University, Kunming, China.
Department of Microbiology and Immunology, School of Basic Medical Sciences, Shanxi Medical University, Taiyuan, China.
Front Microbiol. 2022 May 30;13:875664. doi: 10.3389/fmicb.2022.875664. eCollection 2022.
Allergic diseases have become a primary public health issue in a moderately prosperous society. Colonization of microorganisms early in life appears to be significant in guiding the regulation of childhood immune system maturation and allergy development. Since the oral cavity is the first position where most foreign antigens meet the immune system, the oral microbiota may play a key role in the development of allergies. However, the study on the effects of oral microorganisms on allergy/asthma is very restricted and should be actively investigated. It requires considerable effort to enrich our knowledge in this area of the relationship between the oral cavity and allergy/asthma. To promote the rapid progress of relevant research. In this review, we aimed to provide several insights into the role of the oral microbiota in allergy/asthma while prospecting future directions.
在小康社会中，过敏性疾病已成为一个主要的公共卫生问题。生命早期微生物的定植似乎对引导儿童免疫系统成熟和过敏发展的调节具有重要意义。由于口腔是大多数外来抗原与免疫系统接触的首个部位，口腔微生物群可能在过敏发展中起关键作用。然而，关于口腔微生物对过敏/哮喘影响的研究非常有限，应积极开展调查。要丰富我们在口腔与过敏/哮喘关系这一领域的知识需要付出相当大的努力。为推动相关研究的快速进展。在本综述中，我们旨在对口腔微生物群在过敏/哮喘中的作用提供一些见解，同时展望未来方向。
