Moreno Carlos M, Boeree Ellie, Freitas Claudia M Tellez, Weber K Scott
Department of Microbiology and Molecular Biology, Brigham Young University, Provo, UT, United States.
College of Dental Medicine, Roseman University of Health Sciences, South Jordan, UT, United States.
Front Allergy. 2023 Feb 17;4:1067483. doi: 10.3389/falgy.2023.1067483. eCollection 2023.
In recent years, the interplay between oral microbiota and systemic disease has gained attention as poor oral health is associated with several pathologies. The oral microbiota plays a role in the maintenance of overall health, and its dysbiosis influences chronic inflammation and the pathogenesis of gum diseases. Periodontitis has also been associated with other diseases and health complications such as cancer, neurogenerative and autoimmune disorders, chronic kidney disease, cardiovascular diseases, rheumatic arthritis, respiratory health, and adverse pregnancy outcomes. The host microbiota can influence immune cell development and immune responses, and recent evidence suggests that changes in oral microbiota composition may also contribute to sensitization and the development of allergic reactions, including asthma and peanut allergies. Conversely, there is also evidence that allergic reactions within the gut may contribute to alterations in oral microbiota composition. Here we review the current evidence of the role of the oral microbiota in inflammatory diseases and health complications, as well as its future relevance in improving health and ameliorating allergic disease.
近年来，由于口腔健康状况不佳与多种病症相关，口腔微生物群与全身性疾病之间的相互作用受到了关注。口腔微生物群在维持整体健康方面发挥着作用，其生态失调会影响慢性炎症和牙龈疾病的发病机制。牙周炎还与其他疾病和健康并发症有关，如癌症、神经退行性疾病和自身免疫性疾病、慢性肾病、心血管疾病、风湿性关节炎、呼吸健康以及不良妊娠结局。宿主微生物群可影响免疫细胞发育和免疫反应，最近的证据表明，口腔微生物群组成的变化也可能导致过敏反应的致敏和发展，包括哮喘和花生过敏。相反，也有证据表明肠道内的过敏反应可能导致口腔微生物群组成的改变。在此，我们综述了口腔微生物群在炎症性疾病和健康并发症中的作用的当前证据，以及其在改善健康和缓解过敏性疾病方面的未来相关性。
