Wei Chao, Zhao Jin-Yang, Wang Shu-Ying, Sun Hui-Ning, Guan Nai-Zhe
Department of Blood Transfusion Medicine, Electric Power Teaching Hospital, Capital Medical University, Beijing, China.
Department of Blood Transfusion Medicine, the First Medical Centre, Chinese PLA General Hospital, Beijing, China.
Ann Transl Med. 2022 May;10(10):550. doi: 10.21037/atm-22-1731.
Thromboelastography (TEG) can dynamically evaluate the interaction between platelets and coagulation cascade and the effects of other cellular components on the activities of plasma factors, to comprehensively analyze the whole process of blood coagulation and dissolution. Due to differences in both the incidence rates and the coagulation state of related diseases, many studies have highlighted the necessity of establishing the normal reference ranges for TEG for local regions. The aim of the present study was to determine the local normal reference ranges according to the TEG results of 17,708 volunteers in Beijing, to explore the coagulation characteristics related to the age and sex of the study population.
Reference ranges of reaction time (R), coagulation time (K), coagulation angle (α-angle), and maximum thrombus consistency (MA) for TEG in healthy adults in Beijing were determined in the physical examination of 17,708 Beijing volunteers (5,319 women and 12,389 men). The volunteers were divided into the elderly group (≥60 years old) and young and middle-aged group (20-59 years old), and the reference ranges of each group were calculated according to sex.
Based on the TEG results of the 17,708 volunteers who underwent physical examination, the 95% reference ranges of R, K, α-angle, and MA for TEG in Beijing were 5.1-10 min, 1.3-3.8 min, 44.9-70.2°, and 50.4-71 min, respectively. The results of R, K, α-angle, and MA for TEG between the young and middle-aged group and the elderly group, as well as between women and men were significantly different (P<0.001). Finally, reference ranges for TEG in the young and middle-aged group and the elderly group were obtained.
Compared with the reference standards provided by previous reagent manufacturers, the coagulation factor and fibrinogen function of TEG tend to be hypocoagulable in Beijing population. We found that the young and middle-aged group had lower coagulation activity than the elderly group, and women had higher coagulation activity than men in the same group.
血栓弹力图（TEG）可以动态评估血小板与凝血级联反应之间的相互作用以及其他细胞成分对血浆因子活性的影响，从而全面分析血液凝固和溶解的全过程。由于相关疾病的发病率和凝血状态存在差异，许多研究强调了为当地地区建立TEG正常参考范围的必要性。本研究的目的是根据北京17708名志愿者的TEG结果确定当地的正常参考范围，以探索与研究人群年龄和性别相关的凝血特征。
在对17708名北京志愿者（5319名女性和12389名男性）进行体检时，测定了北京健康成年人TEG的反应时间（R）、凝血时间（K）、凝血角（α角）和最大血栓强度（MA）的参考范围。将志愿者分为老年组（≥60岁）和中青年组（20 - 59岁），并根据性别计算每组的参考范围。
根据17708名接受体检志愿者的TEG结果，北京TEG的R、K、α角和MA的95%参考范围分别为5.1 - 10分钟、1.3 - 3.8分钟、44.9 - 70.2°和50.4 - 71毫米。中青年组和老年组之间以及女性和男性之间TEG的R、K、α角和MA结果存在显著差异（P<0.001）。最终获得了中青年组和老年组TEG的参考范围。
与先前试剂制造商提供的参考标准相比，北京人群中TEG的凝血因子和纤维蛋白原功能倾向于低凝状态。我们发现中青年组的凝血活性低于老年组，并且在同组中女性的凝血活性高于男性。
