Role of LTB4 and nitric oxide in the gastroprotective effect of leaves extract in the indomethacin-induced gastric injury in the rat.

Gastric injury is mainly described by inflammation of the gastric epithelium. Recently, our group of work demonstrated that leaves extract induces both an antioxidative action and an gastroprotective effect in a rat. However, the molecules involved in the gastroprotective action by are not known. Thus, the aim of this study is to determine whether extract modifies anti-inflammatory and antioxidative biomarkers in an model of indomethacin-induced gastric injury. Rats were orally administered with indomethacin and leaf extract. Our results suggest that the gastroprotective effect of leaf extract is related to the reduction in leukocyte infiltration and antioxidative action in a model of indomethacin-induced gastric injury. Further studies are warranted to investigate the role of the compounds identified in the gastroprotective action of leaves extract.