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[掺入酿酒酵母细胞中的氚衰变的遗传效应。I. 3H-丙氨酸对不同倍性细胞的致死效应及放射敏感性]

[Genetic effects of the decay of tritium incorporated into Saccharomyces cerevisiae yeast cells. I. Lethal effect of 3H-alanine on cells of different ploidy and radiosensitivity].

作者信息

Korolev V G, Gracheva L M

出版信息

Genetika. 1978 Feb;14(2):328-33.

PMID:357247
Abstract

Lethal effect of 3H-alanine on cells of different ploidy (1n-4n) and radiosensitivity wild type haploid and diploid strains; xrs2 mutant and diploid strains homozygous for this mutation is studied. It is shown that the efficiency of the inactivation per tritium decay depends on ploidy, radiosensitivity and geometric dimension of cells and nuclei. Do for all the studied strains is slightly higher than Do for these strains in case of external beta-irradiation. RBE of beta-ray tritium with respect to beta-ray of 32P is 1.5.

摘要

研究了³H-丙氨酸对不同倍性(1n - 4n)细胞以及野生型单倍体和二倍体菌株、xrs2突变体及该突变纯合二倍体菌株的致死效应和放射敏感性。结果表明,每一次氚衰变的失活效率取决于细胞和细胞核的倍性、放射敏感性及几何尺寸。所有研究菌株的Do值略高于这些菌株在外部β射线照射情况下的Do值。β射线氚相对于³²P的β射线的相对生物效应(RBE)为1.5。

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