School of Mechanical Engineering, University of Technology Sydney, Sydney, New South Wales 2007, Australia.
School of Biomedical Engineering, University of Technology Sydney, Sydney, New South Wales 2007, Australia.
Drug Discov Today. 2022 Sep;27(9):2593-2602. doi: 10.1016/j.drudis.2022.06.004. Epub 2022 Jun 18.
With the global burden of respiratory diseases, rapid identification of the best therapeutic measures to combat these diseases is essential. Animal models and 2D cell culture models do not replicate the findings observed in vivo. To gain deeper insight into lung pathology and physiology, 3D and advanced lung-on-a-chip models have been developed recently. Lung-on-a-chip models more accurately simulate the lung's microenvironment and functions in vivo, resulting in more-accurate assessments of drug safety and effectiveness. This review discusses the transition from 2D to 3D models and the recent advances in lung-on-a-chip platforms, their implementation and the numerous challenges faced. Finally, a general overview of this platform and its potential applications in respiratory disease research and drug discovery is highlighted.
随着全球呼吸系统疾病负担的增加，快速确定对抗这些疾病的最佳治疗措施至关重要。动物模型和 2D 细胞培养模型无法复制体内观察到的结果。为了更深入地了解肺部病理学和生理学，最近已经开发出 3D 和先进的肺芯片模型。肺芯片模型更准确地模拟了肺部的微环境和体内功能，从而更准确地评估药物的安全性和有效性。本文综述了从 2D 模型向 3D 模型的转变以及肺芯片平台的最新进展，讨论了它们的实施和面临的众多挑战。最后，本文还概述了该平台及其在呼吸道疾病研究和药物发现中的潜在应用。
