Author Affiliations: School of Nursing, Anhui Medical University (Mss Tong, Li, and Feng, and Drs Li, Qiu, and Hong); and the First Affiliated Hospital of Anhui Medical University (Ms Tong), China.
Cancer Nurs. 2023;46(2):E91-E98. doi: 10.1097/NCC.0000000000001055. Epub 2022 Mar 2.
Sleep disturbance is one of the symptoms with high incidence and negative influence in patients with cancer. A better understanding of the biological factors associated with sleep disturbance is critical to predict, treat, and manage this condition.
The aim of this study was to determine the correlation between sleep disturbance and proinflammatory markers in adult patients with cancer.
A systematic search was conducted in 7 databases from inception to March 1, 2020, for this meta-analysis. Two reviewers independently screened the studies, extracted data, and appraised the quality of the studies. Meta-analyses were conducted using Stata 12.0 software.
Sixteen studies were included. Results indicated that sleep disturbance was associated with higher levels of the overall proinflammatory markers and that the effect size was small yet significant. Further subgroup analyses suggested that sleep disturbance was significantly associated with interleukin-6 and C-reactive protein, but not with interleukin-1β or tumor necrosis factor-α. Meta-regression results indicated that only the sample source affected the association between sleep disturbance and proinflammatory markers.
There was a positive relationship between sleep disturbance and selected proinflammatory markers in adult patients with cancer.
This review provides empirical support for the association between sleep disturbance and certain proinflammatory markers. Healthcare providers can further explore specific biomarkers to precisely identify the individuals at risk of sleep disturbance and develop targeted strategies for therapeutic and clinical interventions.
睡眠障碍是癌症患者发病率高且影响负面的症状之一。更好地了解与睡眠障碍相关的生物学因素对于预测、治疗和管理这种情况至关重要。
本研究旨在确定成人癌症患者睡眠障碍与促炎标志物之间的相关性。
对 7 个数据库进行了系统检索，检索时间从建库开始至 2020 年 3 月 1 日，用于本次荟萃分析。两名审查员独立筛选研究、提取数据并评估研究质量。使用 Stata 12.0 软件进行荟萃分析。
纳入了 16 项研究。结果表明，睡眠障碍与整体促炎标志物水平升高有关，且效应量虽小但有统计学意义。进一步的亚组分析表明，睡眠障碍与白细胞介素-6 和 C 反应蛋白显著相关，但与白细胞介素-1β或肿瘤坏死因子-α无关。元回归结果表明，只有样本来源影响睡眠障碍与促炎标志物之间的关联。
在成人癌症患者中，睡眠障碍与某些促炎标志物之间存在正相关关系。
本综述为睡眠障碍与特定促炎标志物之间的关联提供了经验证据。医疗保健提供者可以进一步探索特定的生物标志物，以准确识别存在睡眠障碍风险的个体，并制定针对治疗和临床干预的靶向策略。
