Pagny J Y, Peronnet F, Beliveau L, Sestier F, Nadeau R
J Physiol (Paris). 1986;81(5):368-73.
The purpose of the study was to describe hemodynamic response and regional blood flows through various organs and tissues (microsphere technique) in dogs (n = 8), at rest and during mild (4 km/h, 13% slope; heart rate = 154 bpm), moderate (4 km/h, 26% slope; heart rate = 201 bpm), and severe (4 km/h, 39% slope; heart rate = 266 bpm) exercise on treadmill. Cardiac output (rest: 3.2 +/- 0.3; 39% slope: 10.2 +/- 1.3 l/min; mean +/- SE), systolic aortic pressure (rest: 122 +/- 4; 39% slope: 158 +/- 9 mm Hg), and left atrial pressure (rest: 5 +/- 0.7; 39% slope: 11.0 +/- 0.6 mm Hg) increased linearly with workload. On the contrary stroke volume increased from rest (35 +/- 2 ml) to mild (38 +/- 2 ml) and moderate (42 +/- 3 ml) exercise but decreased in response to the severe workload (38 +/- 5 ml). Regional blood flows across the brain, femoral bone, adrenal glands and temporalis muscle were not modified during exercise. On the contrary, a marked increase in regional blood flow was observed through the flexor and extensor muscles of the limb (X 5 to X 15), the muscles of the back (X 4) and the diaphragm (X 2.5). The small inconsistent increase in nutritional tongue blood flow probably underestimated the increased perfusion through arteriovenous shunts in the mucosa for heat-loss purposes. Myocardial blood flow increased in a linear fashion with work load in both ventricles.(ABSTRACT TRUNCATED AT 250 WORDS)
本研究的目的是描述8只犬在静息状态以及在跑步机上进行轻度（4公里/小时，坡度13%；心率=154次/分钟）、中度（4公里/小时，坡度26%；心率=201次/分钟）和重度（4公里/小时，坡度39%；心率=266次/分钟）运动时的血流动力学反应以及通过各种器官和组织的区域血流量（微球技术）。心输出量（静息：3.2±0.3；坡度39%：10.2±1.3升/分钟；平均值±标准误）、收缩期主动脉压（静息：122±4；坡度39%：158±9毫米汞柱）和左心房压（静息：5±0.7；坡度39%：11.0±0.6毫米汞柱）随工作量呈线性增加。相反，每搏输出量从静息时的（35±2毫升）增加到轻度运动时的（38±2毫升）和中度运动时的（42±3毫升），但在重度工作量时减少（38±5毫升）。运动期间，大脑、股骨、肾上腺和颞肌的区域血流量未发生改变。相反，观察到肢体的屈肌和伸肌（增加5至15倍）、背部肌肉（增加4倍）和膈肌（增加2.5倍）的区域血流量显著增加。营养性舌血流量的微小且不一致的增加可能低估了为散热目的通过黏膜动静脉分流增加的灌注。两个心室的心肌血流量均随工作量呈线性增加。（摘要截短于250字）
