State Key Laboratory of Plant Genomics, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China.
State Key Laboratory of Crop Gene Exploration and Utilization in Southwest China, Sichuan Agricultural University at Wenjiang, Chengdu, Sichuan 611130, China.
J Genet Genomics. 2022 Aug;49(8):693-703. doi: 10.1016/j.jgg.2022.06.003. Epub 2022 Jun 18.
Plant diseases caused by diverse pathogens lead to a serious reduction in crop yield and threaten food security worldwide. Genetic improvement of plant immunity is considered as the most effective and sustainable approach to control crop diseases. In the last decade, our understanding of plant immunity at both molecular and genomic levels has improved greatly. Combined with advances in biotechnologies, particularly clustered regularly interspaced short palindromic repeat (CRISPR)/Cas9-based genome editing, we can now rapidly identify new resistance genes and engineer disease-resistance crop plants like never before. In this review, we summarize the current knowledge of plant immunity and outline existing and new strategies for disease resistance improvement in crop plants. We also discuss existing challenges in this field and suggest directions for future studies.
由多种病原体引起的植物病害导致作物产量严重减少，威胁着全球的粮食安全。提高植物的免疫力被认为是控制作物病害最有效和最可持续的方法。在过去的十年中，我们对植物免疫的分子和基因组水平的理解有了很大的提高。结合生物技术的进步，特别是基于成簇规律间隔短回文重复序列（CRISPR）/Cas9 的基因组编辑技术，我们现在可以以前所未有的速度鉴定新的抗性基因并设计抗病作物。在这篇综述中，我们总结了植物免疫的现有知识，并概述了现有和新的作物抗病改良策略。我们还讨论了该领域现有的挑战，并为未来的研究提出了方向。
