鸭源腺病毒插入缺失突变体。
An insertion and deletion mutant of adenovirus in Muscovy ducks.
机构信息
Key Laboratory of Animal Epidemiology of the Ministry of Agriculture, College of Veterinary Medicine, China Agricultural University, No. 2 Yuanmingyuan West Road, Haidian district, Beijing, 100193, People's Republic of China.
Institute of Animal Husbandry and Veterinary Sciences, Wuhan Academy of Agricultural Sciences, Wuhan, 430208, Hubei, People's Republic of China.
出版信息
Arch Virol. 2022 Sep;167(9):1879-1883. doi: 10.1007/s00705-022-05474-y. Epub 2022 Jun 21.
Duck adenovirus 3 (DuAdV-3; strain HB) was isolated and sequenced. The genome of the Muscovy-duck-origin virus contains a 54-bp insertion in pVIII, a 3-bp deletion in the overlap region of 100K, 22K, and 33K, a 42-bp deletion at the junction of ORF64 and ORF67, and a 715-bp deletion in right noncoding region of the genome. Notably, HB has a strikingly shorter right inverted terminal repeat (ITR) of 50 bp, whereas all other DuAdV-3 isolates have a 721-bp ITR. These findings demonstrate that HB is an insertion and deletion mutant of DuAdV-3.
鸭腺病毒 3（DuAdV-3；株 HB）被分离并测序。该病毒的基因组在 pVIII 中有 54 个碱基的插入，在 100K、22K 和 33K 的重叠区域有 3 个碱基的缺失，在 ORF64 和 ORF67 的连接处有 42 个碱基的缺失，在基因组的右非编码区有 715 个碱基的缺失。值得注意的是，HB 的右反向末端重复（ITR）短得惊人，只有 50 个碱基，而其他所有的 DuAdV-3 分离株的 ITR 则有 721 个碱基。这些发现表明 HB 是 DuAdV-3 的插入和缺失突变体。
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