Gautam Diplesh, Ahmed Nizam, Rao Venkatesh Kp
Department of Mechanical Engineering, BITS Pilani, Pilani, 333031 Rajasthan India.
Bionanoscience. 2022;12(3):867-876. doi: 10.1007/s12668-022-00993-z. Epub 2022 Jun 14.
In recent times, coronavirus (SARS-CoV-2) becomes a pandemic disease across the globe. This virus affects the severe acute respiratory system that causes a type of pneumonia, which results in an outbreak in Wuhan, China, and then in whole global countries. The virus possesses a complex structure and varied in composition along with its geometrical shape and size. Contributions of the lipid and protein components of a virus to the influenza viral envelope's mechanical properties are still unknown. In this work, the virus is modeled like the SARS-CoV-2 and surrounded with spikes made up of S glycoproteins, and numerical analysis was made to predict its mechanical behavior while resting on the substrate. The static and viscoelastic response of the virus was carried out in a finite element (FE) commercial software Ansys. The impact of changing viral envelope thickness on SARS-CoV-2 and bald virus stiffness was investigated. The viscoelastic analysis shows the increase in the deformation and stress with an increase in the pressure. The static analysis predicts the lower stiffness for SARS-CoV-2 compared to bald virion and increases with the increase in the envelop thickness. This study is useful for analyzing the effect of geometry and mechanical properties on the mechanical response of SARS-CoV-2.
近年来，冠状病毒（SARS-CoV-2）在全球范围内成为一种大流行病。这种病毒影响严重急性呼吸系统，引发一种肺炎，首先在中国武汉爆发，随后蔓延至全球各国。该病毒结构复杂，其几何形状和大小以及组成成分各不相同。病毒的脂质和蛋白质成分对流感病毒包膜机械性能的贡献仍不清楚。在这项工作中，将病毒建模为SARS-CoV-2，并被由S糖蛋白组成的刺突包围，进行了数值分析以预测其在置于基质上时的力学行为。病毒的静态和粘弹性响应在有限元（FE）商业软件Ansys中进行。研究了改变病毒包膜厚度对SARS-CoV-2和无包膜病毒刚度的影响。粘弹性分析表明，随着压力增加，变形和应力也增加。静态分析预测，与无包膜病毒粒子相比，SARS-CoV-2的刚度较低，且随着包膜厚度的增加而增加。这项研究有助于分析几何形状和力学性能对SARS-CoV-2力学响应的影响。
