Dahlström A
Acta Pharmacol Toxicol (Copenh). 1978;43 Suppl 2:19-25. doi: 10.1111/j.1600-0773.1978.tb03214.x.
The adrenergic innervation of the feline and human urinary bladder was studied with the histochemical fluorescence method of Hillarp and Falck. In the normal bladder of both species the trigone area was densely innervated by thick and strongly green-fluorescent adrenergic terminals while the detrusor muscle contained a sparse innervation of very thin and weakly fluorescent nerve terminals. After parasympathetic denervation (lower motor neuron lesion in patients) the adrenergic innervation of the detrusor muscle was altered. In the cat, the first signs of altered adrenergic innervation were observed 6 weeks after parasympathetic denervation, when thick, strongly fluorescent adrenergic fibres appeared between and in the smooth muscle bundles. These fibres had the characteristics of growth cones and indicated an outgrowth of new adrenergic fibres into the detrusor muscle. Later on, the muscle bundles were densely innervated by thick and strongly fluorescent terminals, reminiscent of trigone terminals. In the patients with lower motor neuron lesions, thick, strongly fluorescent adrenergic terminals were seen in the detrusor. In both cat and man the appearance of this "new" type of adrenergic nerve terminal in the detrusor muscle coincided with the presence of alpha-adrenoceptor function (rather than the normal beta-adrenoceptor activity of the feline and human detrusor).
采用希勒普（Hillarp）和法尔克（Falck）的组织化学荧光法，对猫和人类膀胱的肾上腺素能神经支配进行了研究。在这两个物种的正常膀胱中，三角区由粗大且发出强烈绿色荧光的肾上腺素能终末密集支配，而逼尿肌则由非常细且荧光较弱的神经终末稀疏支配。在副交感神经去神经支配后（患者为下运动神经元损伤），逼尿肌的肾上腺素能神经支配发生了改变。在猫身上，副交感神经去神经支配6周后观察到肾上腺素能神经支配改变的最初迹象，此时粗大、强荧光的肾上腺素能纤维出现在平滑肌束之间及其中。这些纤维具有生长锥的特征，表明有新的肾上腺素能纤维长入逼尿肌。后来，肌束由粗大且强荧光的终末密集支配，类似于三角区的终末。在患有下运动神经元损伤的患者中，在逼尿肌中可见粗大、强荧光的肾上腺素能终末。在猫和人类中，逼尿肌中这种“新”类型的肾上腺素能神经终末的出现与α - 肾上腺素能受体功能的存在相一致（而不是猫和人类逼尿肌正常的β - 肾上腺素能受体活性）。
