Petenusci S O, Lopes R A, Silva Netto C R
Int J Vitam Nutr Res. 1980;50(3):238-41.
Administration of excess vitamin A doses to rats causes atrophy of the thyroid, with smaller follicles, more abundant cytoplasm, less colloid and decreased nuclear volume. The connective tissue were more abundant. In order to determine the possible reversibility of these alterations, the authors allowed the hypervitaminotic animals to recover for 30 days. After the recovery period, the glandular lesions were reversed to normal. These data were confirmed with morphometric technique.
给大鼠过量服用维生素A会导致甲状腺萎缩，甲状腺滤泡变小，细胞质增多，胶体减少，核体积减小。结缔组织更为丰富。为了确定这些改变是否可能可逆，作者让维生素A过量的动物恢复30天。恢复期过后，腺体病变恢复正常。这些数据通过形态计量学技术得到了证实。
